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1. (WO2016186346) METHOD FOR INDUCING OLIGODENDROCYTE PRECURSOR CELLS FROM OCT4-INDUCED HUMAN SOMATIC CELLS THROUGH DIRECT REPROGRAMMING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/186346    International Application No.:    PCT/KR2016/004603
Publication Date: 24.11.2016 International Filing Date: 02.05.2016
IPC:
C12N 5/00 (2006.01), C12N 15/85 (2006.01)
Applicants: STEMLAB INC. [KR/KR]; #711, TechnoComplex of Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841 (KR)
Inventors: YOU, Seung Kwon; (KR).
YUN, Won-Jin; (KR).
PARK, Min Ji; (KR).
PARK, Ji-Yong; (KR)
Agent: LEE, Cheo Young; (KR)
Priority Data:
10-2015-0069696 19.05.2015 KR
10-2016-0043593 08.04.2016 KR
Title (EN) METHOD FOR INDUCING OLIGODENDROCYTE PRECURSOR CELLS FROM OCT4-INDUCED HUMAN SOMATIC CELLS THROUGH DIRECT REPROGRAMMING
(FR) PROCÉDÉ POUR INDUIRE DES CELLULES PRÉCURSEURS D'OLIGODENDROCYTES À PARTIR DE CELLULES SOMATIQUES HUMAINES INDUITES PAR OCT4 PAR REPROGRAMMATION DIRECTE
(KO) Oct4가 도입된 인간체세포로부터 직접적 리프로그래밍을 통한 희소돌기아교 전구세포를 유도하는 방법
Abstract: front page image
(EN)The present invention relates to a method for inducing oligodendrocyte precursor cells from human somatic cells, into which a nucleic acid molecule coding Oct4 protein is introduced, or human somatic cells treated with Oct4 protein, through direct reprogramming. The method for inducing oligodendrocyte precursor cells by treating Oct4-overexpressed human somatic cells with a low-molecular weight material, according to the present invention, can establish oligodendrocyte precursor cells at high efficiency for a short period of time, through direct reprogramming without going through neural stem cells, and thus the oligodendrocyte precursor cells are useful as a cell therapeutic agent for intractable demyelinating diseases.
(FR)La présente invention concerne un procédé d'induction de cellules précurseurs d'oligodendrocytes à partir de cellules somatiques humaines, dans lequel une molécule d'acide nucléique codant pour une protéine Oct4 est introduite, ou de cellules somatiques humaines traitées par une protéine Oct4, par reprogrammation directe. Le procédé d'induction de cellules précurseurs d'oligodendrocytes par traitement de cellules somatiques humaines à Oct 4 surexprimée avec un matériau de faible poids moléculaire, selon la présente invention, permet d'établir des cellules précurseurs d'oligodendrocytes avec une efficacité élevée en une courte période de temps, par reprogrammation directe sans passer par des cellules souches neurales, et, par conséquent, les cellules précurseurs d'oligodendrocytes sont utiles en tant qu'agent thérapeutique cellulaire pour des maladies démyélinisantes incurables.
(KO)본 발명은 Oct4 단백질을 코딩하는 핵산분자가 도입된 인간 체세포 또는 Oct4 단백질이 처리된 인간 체세포로부터 직접적 리프로그래밍을 통해 희소돌기아교 전구세포를 유도하는 방법에 관한 것이다. 본 발명에 따른 Oct4가 과발현된 인간체세포에 저분자성 물질을 처리하여 희소돌기아교 전구세포를 유도하는 방법은 신경줄기세포를 거치지 않는 직접적 리프로그래밍을 통하여 단기간 동안 고효율로 희소돌기아교 전구세포를 확립할 수 있어, 난치성 탈수초성 질환의 세포치료제로 유용하다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)