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1. (WO2016186259) VERSATILE CANINE INFLUENZA VIRUS VACCINE COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/186259    International Application No.:    PCT/KR2015/009617
Publication Date: 24.11.2016 International Filing Date: 14.09.2015
IPC:
A61K 38/16 (2006.01), A61K 39/12 (2006.01), A61K 48/00 (2006.01), A61K 39/39 (2006.01)
Applicants: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 125, Gwahak-ro Yuseong-gu Daejeon 34141 (KR)
Inventors: JEONG, Dae Gwin; (KR).
SONG, Dae Sub; (KR).
KIM, Jeong Kie; (KR)
Agent: KIM, Soon Woong; (KR)
Priority Data:
10-2015-0069077 18.05.2015 KR
Title (EN) VERSATILE CANINE INFLUENZA VIRUS VACCINE COMPOSITION
(FR) COMPOSITION DE VACCIN POLYVALENT CONTRE LE VIRUS DE LA GRIPPE CANINE
(KO) 범용성 개 인플루엔자 바이러스 백신 조성물
Abstract: front page image
(EN)The present invention relates to a versatile canine influenza virus vaccine composition using the HA2 helical domain of a hemagglutinin protein, which is an influenza surface protein, and to a pharmaceutical composition for preventing or treating canine influenza virus infectious diseases. The polypeptide represented by SEQ ID NO: 3 and the polypeptide expressed by residues 379 to 474 of SEQ ID NO: 1 of the present invention can be mass-produced in E. coli, effectively produce neutralizing antibodies to various canine influenza virus subtypes, and boost an immune induction effect of the existing canine influenza vaccine through combined administration, and thus the polypeptides can be widely utilized as versatile vaccines for influenza virus subtypes and new influenza virus variants.
(FR)La présente invention concerne une composition de vaccin polyvalent contre le virus de la grippe canine utilisant le domaine hélicoïdal HA2 d'une protéine, l'hémagglutinine, qui est une protéine de surface du virus de la grippe, ainsi qu'une composition pharmaceutique visant à prévenir ou traiter les maladies infectieuses impliquant le virus de la grippe canine. Le polypeptide représenté par SEQ ID NO : 3 et le polypeptide exprimé par les résidus 379 à 474 de la SEQ ID NO : 1 de la présente invention peuvent être produits en masse dansE. coli, produisent de manière efficace des anticorps neutralisants dirigés contre divers sous-types du virus de la grippe canine, et renforcent l'effet d'induction immunitaire du vaccin contre la grippe canine existant par administration combinée, et, de ce fait, ces polypeptides peuvent être largement utilisés en tant que vaccins polyvalents contre divers sous-types du virus de la grippe et de nouveaux variants du virus de la grippe.
(KO)본 발명은 인플루엔자 표면 단백질인 헤마글루티닌 단백질의 HA2 헬리컬 도메인을 이용한 범용성 개 인플루엔자 바이러스 백신 조성물 및 개 인플루엔자 감염 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명의 서열번호 3으로 표시되는 폴리펩티드 및 서열번호 1의 379 내지 474 잔기로 표시되는 폴리펩티드는 대장균에서 대량 생산이 가능하고 다양한 개 인플루엔자 아형에 대하여 중화항체를 효과적으로 생산할 수 있을 뿐만 아니라 복합 투여를 통해 기존 개 인플루엔자 백신의 면역 유도 효과를 증강시킬 수 있으므로 인플루엔자 아형 및 신종 변이 인플루엔자에 대한 범용성 백신으로 널리 활용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)