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1. WO2016185485 - PROCESS FOR THE PREPARATION OF N-[4-[(3-CHLORO-4-FLUORO PHENYL) AMINO]-7-[[(3S)-TETRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4- (DIMETHYL AMINO)-(2E)-2-BUTENAMIDE (2Z)-2-BUTENEDIOATE (1 :2) AND ITS POLYMORPHS THEREOF

Publication Number WO/2016/185485
Publication Date 24.11.2016
International Application No. PCT/IN2016/000123
International Filing Date 11.05.2016
IPC
C07D 407/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
B01D 9/005
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
9Crystallisation
005Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • MSN LABORATORIES PRIVATE LIMITED [IN]/[IN]
  • THIRUMALAI RAJAN, Srinivasan [IN]/[IN]
  • ESWARAIAH, Sajja [IN]/[IN]
  • VENKATA PANAKALA RAO, Gogulapati [IN]/[IN]
  • RAJESHAM, Boge [IN]/[IN]
Inventors
  • ESWARAIAH, Sajja
  • VENKATA PANAKALA RAO, Gogulapati
  • RAJESHAM, Boge
Common Representative
  • THIRUMALAI RAJAN, Srinivasan
Priority Data
2476/CHE/201518.05.2015IN
5555/CHE/201516.10.2015IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF N-[4-[(3-CHLORO-4-FLUORO PHENYL) AMINO]-7-[[(3S)-TETRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4- (DIMETHYL AMINO)-(2E)-2-BUTENAMIDE (2Z)-2-BUTENEDIOATE (1 :2) AND ITS POLYMORPHS THEREOF
(FR) PROCÉDÉ POUR LA PRÉPARATION DE N-[4-[(3-CHLORO-4-FLUORO-PHÉNYL)AMINO]-7-[[(3S)-TÉTRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4-(DIMÉTHYL-AMINO)-(2E)-2-BUTÉNAMIDE(2Z)-2-BUTÈNEDIOATE (1 : 2) ET DE SES FORMES POLYMORPHES
Abstract
(EN)
The present invention relates to an improved process for the preparation of N-[4-[(3- chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1 :2) represented by the following structural formula:
(FR)
La présente invention concerne un procédé amélioré pour la préparation de N-[4-[(3-chloro-4-fluorophényl) amino]-7-[[ (3S)-tétrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diméthyl-amino)-(2E)-2-buténamide (2Z)-2-butènedioate (1 : 2) représenté par la formule structurelle suivante :
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