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1. (WO2016185485) PROCESS FOR THE PREPARATION OF N-[4-[(3-CHLORO-4-FLUORO PHENYL) AMINO]-7-[[(3S)-TETRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4- (DIMETHYL AMINO)-(2E)-2-BUTENAMIDE (2Z)-2-BUTENEDIOATE (1 :2) AND ITS POLYMORPHS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/185485    International Application No.:    PCT/IN2016/000123
Publication Date: 24.11.2016 International Filing Date: 11.05.2016
IPC:
C07D 407/12 (2006.01)
Applicants: MSN LABORATORIES PRIVATE LIMITED [IN/IN]; SY.No: 317 & 323, Rudraram (Vil), Patancheru (Mdl), Medak (Dist), Hyderabad, Telangana (IN).
THIRUMALAI RAJAN, Srinivasan [IN/IN]; (IN).
ESWARAIAH, Sajja [IN/IN]; (IN).
VENKATA PANAKALA RAO, Gogulapati [IN/IN]; (IN).
RAJESHAM, Boge [IN/IN]; (IN)
Inventors: ESWARAIAH, Sajja; (IN).
VENKATA PANAKALA RAO, Gogulapati; (IN).
RAJESHAM, Boge; (IN)
Common
Representative:
THIRUMALAI RAJAN, Srinivasan; (IN)
Priority Data:
2476/CHE/2015 18.05.2015 IN
5555/CHE/2015 16.10.2015 IN
Title (EN) PROCESS FOR THE PREPARATION OF N-[4-[(3-CHLORO-4-FLUORO PHENYL) AMINO]-7-[[(3S)-TETRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4- (DIMETHYL AMINO)-(2E)-2-BUTENAMIDE (2Z)-2-BUTENEDIOATE (1 :2) AND ITS POLYMORPHS THEREOF
(FR) PROCÉDÉ POUR LA PRÉPARATION DE N-[4-[(3-CHLORO-4-FLUORO-PHÉNYL)AMINO]-7-[[(3S)-TÉTRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4-(DIMÉTHYL-AMINO)-(2E)-2-BUTÉNAMIDE(2Z)-2-BUTÈNEDIOATE (1 : 2) ET DE SES FORMES POLYMORPHES
Abstract: front page image
(EN)The present invention relates to an improved process for the preparation of N-[4-[(3- chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1 :2) represented by the following structural formula:
(FR)La présente invention concerne un procédé amélioré pour la préparation de N-[4-[(3-chloro-4-fluorophényl) amino]-7-[[ (3S)-tétrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diméthyl-amino)-(2E)-2-buténamide (2Z)-2-butènedioate (1 : 2) représenté par la formule structurelle suivante :
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)