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1. (WO2016185481) METHOD OF TARGETING SENESCENT CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/185481    International Application No.:    PCT/IL2016/050535
Publication Date: 24.11.2016 International Filing Date: 19.05.2016
IPC:
A61K 47/48 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot (IL)
Inventors: KRIZHANOVSKY, Valery; (IL).
OVADYA, Yossi; (IL)
Agent: EHRLICH, Gal; (IL)
Priority Data:
62/164,025 20.05.2015 US
Title (EN) METHOD OF TARGETING SENESCENT CELLS
(FR) PROCÉDÉ DESTINÉ À CIBLER DES CELLULES SÉNESCENTES
Abstract: front page image
(EN)A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.
(FR)La présente invention concerne un procédé pour diriger un agent pharmaceutique vers une cellule sénescente. Le procédé consiste à administrer l'agent pharmaceutique au sujet, ledit agent pharmaceutique étant fixé à une fraction d'affinité, ladite fraction d'affinité étant apte à se lier spécifiquement à un polypeptide choisi dans le groupe constitué par HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 et un polypeptide présenté dans le Tableau 1. Ce procédé destiné à cibler des cellules peut être mis en œuvre à des fins de thérapie ou de diagnostic.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application