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1. (WO2016185471) COMPOSITIONS AND METHODS FOR TREATING CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/185471    International Application No.:    PCT/IL2016/050522
Publication Date: 24.11.2016 International Filing Date: 17.05.2016
IPC:
C12N 15/09 (2006.01), A61K 48/00 (2006.01), C12N 15/86 (2006.01), A61K 31/7088 (2006.01), C12N 15/861 (2006.01), C12N 15/31 (2006.01)
Applicants: THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER [IL/IL]; 6 Weizmann Street 6423906 Tel-Aviv (IL)
Inventors: ARBER, Nadir; (IL).
SHAPIRA, Shiran; (IL).
KAZANOV, Dina; (IL)
Agent: EHRLICH , Gal; G.E. Ehrlich (1995) LTD. 11 Menachem Begin Road 5268104 Ramat Gan (IL)
Priority Data:
62/162,765 17.05.2015 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING CANCER
(FR) COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Provided are nucleic acid constructs and systems which comprise (i) a first nucleic acid construct encoding a toxin operatively linked to a first promoter and at least one cancer-associated signaling responsive enhancer element; and (ii) a second nucleic acid construct encoding an anti-toxin operatively linked to a second promoter, the second promoter being stronger than the first promoter. Also provided are pharmaceutical compositions comprising same and methods of using same for treating cancer.
(FR)L'invention concerne des constructions et des systèmes d'acide nucléique qui comprennent (i) une première construction d'acide nucléique codant pour une toxine liée de manière fonctionnelle à un premier promoteur et au moins un activateur sensible de signalisation associé au cancer; et (ii) une seconde construction d'acide nucléique codant pour une anti-toxine liée de manière fonctionnelle à un second promoteur, le second promoteur étant plus fort que le premier promoteur. L'invention concerne également des compositions pharmaceutiques les comprenant et des procédés d'utilisation de celles-ci pour le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)