WO2016185342 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

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Publication Number WO/2016/185342

Publication Date 24.11.2016

International Application No. PCT/IB2016/052773

International Filing Date 13.05.2016

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Applicants

AURIGENE DISCOVERY TECHNOLOGIES LIMITED [IN]/[IN]

Inventors

KOTRABASAIAH UJJINAMATADA, Ravi
PANDIT, Chetan

Priority Data

2448/CHE/2015

15.05.2015

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

(FR) COMPOSÉS TÉTRAHYDROQUINOLINONE SUBSTITUÉS EN TANT QUE MODULATEURS DE ROR GAMMA

Abstract

(EN) The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

(FR) La présente invention concerne des composés de tétrahydroquinolinone substitués et des composés apparentés de formule (I), qui sont thérapeutiquement utiles en tant que modulateurs de récepteurs orphelins apparentés (ROR) au récepteur de l’acide rétinoïque, plus particulièrement en tant que modulateurs RORγ. Ces composés sont destinés au traitement et à la prévention de maladies et/ou d'un trouble, en particulier destinés à des maladies et/ou à un trouble induits par récepteur RORγ. L'invention concerne également la préparation des composés et des formulations pharmaceutiques comprenant la tétrahydroquinolinone substituée et/ou des composés apparentés de formule (I), ensemble avec un vecteur, diluant, ou excipient pharmaceutiquement acceptable correspondant.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
215	Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36	Sulfur atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
215	Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36	Sulfur atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines
4709	Non-condensed quinolines and containing further heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines
472	Non-condensed isoquinolines, e.g. papaverine
4725	containing further heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4985	Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

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1. WO2016185342 - SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system