GB2016051057 COMPOUNDS

1. (WO2016185160) COMPOUNDS

↓

Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2016/185160		International Application No.:		PCT/GB2016/051057
Publication Date:		24.11.2016		International Filing Date:		15.04.2016

IPC:

C07D 487/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01), A61P 31/12 (2006.01), A61P 25/28 (2006.01)

Applicants:

THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH [GB/GB]; Old College South Bridge Edinburgh EH8 9YL (GB)

Inventors:

UNCITI-BROCETA, Asier; (GB).
FRASER, Craig; (GB).
O. CARRAGHER, Neil; (GB)

Agent:

CLYDE-WATSON, Zoe; (GB)

Priority Data:

1508747.1

21.05.2015

Title

(EN) COMPOUNDS
(FR) COMPOSÉS

Abstract:

(EN)A first aspect of the- invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R₁ is (CH₂)_mNR₁₁R₁₂;R₂ is selected from H, halo, OR₁₃, ΝΗR₁₃, alkyl, alkenyl and alkynyl; R₃ is selected from alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO₂R₄, NHCONR₅R₆, NHCOR₇, NH-alkyl, NH-alkenyl, NH(CH₂);_n-aryl, (CH₂)_p-heteroaryl, (CH₂)_qCO₂R₈, (CH₂)_rCOR₉ and NHSO₂R₁₀, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo OH, NH₂, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R₄ to R₁₀ and R₁₃ are each independently selected from alkyl, alkenyl and aryl; R₁₁ and R₁₂ are each independently selected from alkyl and alkenyl; or R₁₁ and R:₁₂ are linked together with the nitrogen to which they are attached to form a heterocycloalkyl or heterocycloalkenyl group; n, m, p, q and r are each independently selected from 0, 1, 2,.3. 4, 5 and 6. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing according to the invention.
(FR)Un premier aspect de la présente invention concerne un composé de formule (I), ou un sel ou ester pharmaceutiquement acceptable de celui-ci, (formule (I)), dans laquelle : R₁ est (CH₂)_mNR₁₁R₁₂ ; R₂ est choisi parmi H, halogéno, OR₁₃, ΝΗR₁₃, alkyle, alcényle et alcynyle ; R₃ est choisi parmi alkyle, alcényle, alcynyle, aryle, halogéno, aryloxy, NHCO₂R₄, NHCONR₅R₆, NHCOR₇, NH-alkyle, NH-alcnéyle, NH(CH₂);_n-aryle, (CH₂)_p-hétéroaryle, (CH₂)_qCO₂R₈, (CH₂)_rCOR₉ et NHSO₂R₁₀, chaque fraction d'alkyle, d'alcényle, d'aryle ou d'hétéroaryle de la liste mentionnée ci-dessus étant facultativement davantage remplacée par un ou plusieurs groupes choisis parmi alkyle, halogéno, OH, NH₂, alcoxy, aryloxy, alkylamino, arylamino, carboxyle et carboxamide ; R₄ à R₁₀ et R₁₃ sont choisis chacun indépendamment parmi alkyle, alcényle et aryle ; R₁₁ et R₁₂ sont choisis chacun indépendamment parmi alkyle et alcényle ; ou R₁₁ et R₁₂ sont liés ensemble avec l'atome d'azote auquel ils sont fixés pour former un groupe hétérocycloalkyle ou hétérocycloalcényle ; n, m, p, q et r sont chacun indépendamment choisis parmi 0,1,2, 3. 4, 5 et 6. D'autres aspects de l'invention concernent des compositions pharmaceutiques, des utilisations thérapeutiques et des procédés de préparation.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

Default Search Form
Default Tab Search Form
Interface Language
Skins
Multiple Windows Interface
Tooltip Help
IPC Tooltip Help