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1. (WO2016185160) COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/185160    International Application No.:    PCT/GB2016/051057
Publication Date: 24.11.2016 International Filing Date: 15.04.2016
IPC:
C07D 487/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01), A61P 31/12 (2006.01), A61P 25/28 (2006.01)
Applicants: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH [GB/GB]; Old College South Bridge Edinburgh EH8 9YL (GB)
Inventors: UNCITI-BROCETA, Asier; (GB).
FRASER, Craig; (GB).
O. CARRAGHER, Neil; (GB)
Agent: CLYDE-WATSON, Zoe; (GB)
Priority Data:
1508747.1 21.05.2015 GB
Title (EN) COMPOUNDS
(FR) COMPOSÉS
Abstract: front page image
(EN)A first aspect of the- invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R1 is (CH2)mNR11R12;R2 is selected from H, halo, OR13, ΝΗR13, alkyl, alkenyl and alkynyl; R3 is selected from alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyl, NH-alkenyl, NH(CH2);n-aryl, (CH2)p-heteroaryl, (CH2)qCO2R8, (CH2)rCOR9 and NHSO2R10, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo OH, NH2, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R4 to R10 and R13 are each independently selected from alkyl, alkenyl and aryl; R11 and R12 are each independently selected from alkyl and alkenyl; or R11 and R:12 are linked together with the nitrogen to which they are attached to form a heterocycloalkyl or heterocycloalkenyl group; n, m, p, q and r are each independently selected from 0, 1, 2,.3. 4, 5 and 6. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing according to the invention.
(FR)Un premier aspect de la présente invention concerne un composé de formule (I), ou un sel ou ester pharmaceutiquement acceptable de celui-ci, (formule (I)), dans laquelle : R1 est (CH2)mNR11R12 ; R2 est choisi parmi H, halogéno, OR13, ΝΗR13, alkyle, alcényle et alcynyle ; R3 est choisi parmi alkyle, alcényle, alcynyle, aryle, halogéno, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyle, NH-alcnéyle, NH(CH2);n-aryle, (CH2)p-hétéroaryle, (CH2)qCO2R8, (CH2)rCOR9 et NHSO2R10, chaque fraction d'alkyle, d'alcényle, d'aryle ou d'hétéroaryle de la liste mentionnée ci-dessus étant facultativement davantage remplacée par un ou plusieurs groupes choisis parmi alkyle, halogéno, OH, NH2, alcoxy, aryloxy, alkylamino, arylamino, carboxyle et carboxamide ; R4 à R10 et R13 sont choisis chacun indépendamment parmi alkyle, alcényle et aryle ; R11 et R12 sont choisis chacun indépendamment parmi alkyle et alcényle ; ou R11 et R12 sont liés ensemble avec l'atome d'azote auquel ils sont fixés pour former un groupe hétérocycloalkyle ou hétérocycloalcényle ; n, m, p, q et r sont chacun indépendamment choisis parmi 0,1,2, 3. 4, 5 et 6. D'autres aspects de l'invention concernent des compositions pharmaceutiques, des utilisations thérapeutiques et des procédés de préparation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)