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1. (WO2016184663) METHIONINE PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/184663    International Application No.:    PCT/EP2016/059619
Publication Date: 24.11.2016 International Filing Date: 29.04.2016
IPC:
C12N 15/52 (2006.01), C12R 1/00 (2006.01)
Applicants: EVONIK DEGUSSA GMBH [DE/DE]; Rellinghauser Straße 1-11 45128 Essen (DE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
HAAS, Thomas [DE/DE]; (DE) (US only).
BÜLTER, Thomas [DE/DE]; (DE) (US only).
HECKER, Anja [DE/DE]; (DE) (US only)
Inventors: HAAS, Thomas; (DE).
BÜLTER, Thomas; (DE).
HECKER, Anja; (DE)
Priority Data:
15168106.1 19.05.2015 EP
Title (EN) METHIONINE PRODUCTION
(FR) PRODUCTION DE MÉTHIONINE
Abstract: front page image
(EN)The present invention relates to a microbial cell capable of producing at least one acetylhomoserine from 4-acetyl-butyric acid and/or ester thereof, wherein the cell is genetically modified to comprise -at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme E1 capable of catalysing the hydroxylation of 4-acetyl-butyric acid and/or ester thereof to an alpha-hydroxy acetyl butanone, and -at least a second genetic mutation that increases the expression relative to the wild type cell of enzyme E2 capable of catalysing the amination of the alpha-hydroxy acetyl butanone to the acetylhomoserine.
(FR)La présente invention concerne une cellule microbienne qui peut produire au moins une acétylhomosérine à partir de l'acide 4-acétyl-butyrique et/ou d'un ester de celui-ci, la cellule étant génétiquement modifiée pour comprendre - au moins une première mutation génétique qui augmente l'expression par rapport à la cellule de type sauvage de l'enzyme E1 pouvant catalyser l'hydroxylation de l'acide 4-acétyl-butyrique et/ou d'un ester de celui-ci en une alpha-hydroxy acétyl butanone, et - au moins une seconde mutation génétique qui augmente l'expression par rapport à la cellule de type sauvage de l'enzyme E2 pouvant catalyser l'amination de l'alpha-hydroxy acétyl butanone en acétylhomosérine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)