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1. (WO2016184437) IMIDAZO-PYRIMIDONE COMPOUNDS, AND PREPARATION METHOD AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2016/184437 International Application No.: PCT/CN2016/086145
Publication Date: 24.11.2016 International Filing Date: 17.06.2016
IPC:
C07D 471/14 (2006.01) ,C07D 487/14 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/5377 (2006.01) ,A61K 31/519 (2006.01)
Applicants: NANJING GATOR MEDITECH COMPANY, LTD.[CN/CN]; Suite 6, No.3 Gutan Rd, Gaochun Nanjing, Jiangsu 210000, CN
Inventors: XU, Ruo; CN
LIU, Yunyong; CN
Agent: SHIJIAZHUANG GUOYU PATENT TRADEMARK AGENCY; 334 Heping West Road, Xinhua District Shijiazhuang, Hebei 050071, CN
Priority Data:
201510250497.715.05.2015CN
Title (EN) IMIDAZO-PYRIMIDONE COMPOUNDS, AND PREPARATION METHOD AND APPLICATION THEREOF
(FR) COMPOSÉS IMIDAZO-PYRIMIDONE, ET PROCÉDÉ DE PRÉPARATION ET APPLICATION ASSOCIÉS
(ZH) 咪唑并嘧啶酮类化合物及其制备方法和应用
Abstract: front page image
(EN) Disclosed are imidazo-pyrimidone compounds as shown in formula (I), and a preparation method and an application of said compounds. n, R and Ar are described in the description. The compounds and pharmaceutically acceptable salts thereof trigger the production of the tumour necrosis factor-related apoptosis-inducing ligand in the human body, and also prevent the misuse of existing recombinant protein and antibody-based treatment means, thereby providing a new choice for related tumour treatment.
(FR) L'invention concerne des composés imidazo-pyrimidone tels que représentés dans la formule (I), et un procédé de préparation et une application de ces composés. n, R et Ar sont tels que décrits dans la description. Les composés et leurs sels pharmaceutiquement acceptables déclenchent la production du ligand induisant l'apoptose associé au facteur de nécrose tumorale dans le corps humain, et évitent également la mauvaise utilisation d'une protéine de recombinaison existante et des moyens de traitement à base d'anticorps, ce qui fournit un nouveau choix pour le traitement d'une tumeur associée.
(ZH) 本发明公开了式(I)所示咪唑并嘧啶酮类化合物及其制备方法和应用。其中,n、R和Ar如说明书所述,本发明的化合物及其药学上可接受的盐可以激发人体肿瘤坏死因子相关凋亡诱导配体的产生,同时能避免现有基于重组蛋白和抗体的治疗方式的弊端,从而为相关肿瘤的治疗提供新的选择。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)