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1. (WO2016184400) NOVEL 18Α-GLYCYRRHETINIC ACID DERIVATIVE AND PHARMACEUTICAL USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/184400    International Application No.:    PCT/CN2016/082646
Publication Date: 24.11.2016 International Filing Date: 19.05.2016
IPC:
C07J 63/00 (2006.01), A61K 31/56 (2006.01), A61P 1/16 (2006.01), A61P 31/14 (2006.01)
Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD [CN/CN]; No.369 Yuzhou South Rd., Haizhou District Lianyungang, Jiangsu 222062 (CN)
Inventors: ZHANG, Xiquan; (CN).
ZHANG, Aiming; (CN).
XU, Hongjiang; (CN).
DONG, Ping; (CN).
ZHOU, Hao; (CN).
TIAN, Xin; (CN)
Agent: BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD.; 16th Fl., Block A, Corporate Square No.35 Jinrong Street Beijing 100033 (CN)
Priority Data:
201510258072.0 19.05.2015 CN
Title (EN) NOVEL 18Α-GLYCYRRHETINIC ACID DERIVATIVE AND PHARMACEUTICAL USE THEREOF
(FR) NOUVEAU DÉRIVÉ D'ACIDE 18Α-GLYCYRRHÉTINIQUE ET UTILISATION PHARMACEUTIQUE DE CELUI-CI
(ZH) 一种新的18α-甘草次酸衍生物及其医药用途
Abstract: front page image
(EN)The present invention relates to a novel 18α-glycyrrhetinic acid derivative and pharmaceutical use thereof. The compound has a weak inhibitory activity on 11β-hydroxyl steroid dehydrogenase, thus effectively alleviating an adrenocortical hormone-like adverse effects of glycyrrhetinic acid medicine, and reducing risk of water and sodium retention.
(FR)La présente invention concerne un nouveau dérivé d'acide 18α-glycyrrhétinique et l'utilisation pharmaceutique de celui-ci. Le composé a une faible activité inhibitrice sur la 11β-hydroxystéroïde déshydrogénase, ce qui permet d'atténuer efficacement les effets indésirables hormonoides corticosurrénaux des médicaments à l'acide glycyrrhétinique, et de réduire le risque de rétention d'eau et de sodium.
(ZH)本发明涉及一种新的18α-甘草次酸衍生物及其医药用途。该化合物对11β-羟基类固醇脱氢酶抑制弱,能够有效改善甘草次酸类药物的肾上腺皮质激素样类不良反应,降低水钠潴留风险。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)