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1. (WO2016184274) STAPHYLOCOCCUS LYASE AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/184274    International Application No.:    PCT/CN2016/079044
Publication Date: 24.11.2016 International Filing Date: 12.04.2016
IPC:
C12N 9/88 (2006.01), C12N 15/60 (2006.01), C12N 15/70 (2006.01), C12Q 1/68 (2006.01), C12Q 1/66 (2006.01), C12Q 1/527 (2006.01), C12Q 1/14 (2006.01), A61K 38/51 (2006.01), A61P 31/04 (2006.01)
Applicants: WUHAN PHAGELUX BIO-TECH COMPANY LIMITED [CN/CN]; Exhibition Center,A7 Bio-medicine Park No. 858 Gaoxin Avenue, Donghu Hi-Tech Development Zone Wuhan City,, Hubei 430075 (CN)
Inventors: WEI, Hongping; (CN).
YANG, Hang; (CN).
YU, Junping; (CN)
Agent: BEIJING LONGAN LAW FIRM; Room 188,Beijing International Club 21 Jianguomenwai Street,Chaoyang District Beijing 100020 (CN)
Priority Data:
201510252947.6 18.05.2015 CN
Title (EN) STAPHYLOCOCCUS LYASE AND USE THEREOF
(FR) STAPHYLOCOQUE LYASE ET SON UTILISATION
(ZH) 一种葡萄球菌裂解酶及其应用
Abstract: front page image
(EN)Provided is a lyase that can kill staphylococcus and a use thereof, wherein the amino acid sequence and the encoding gene sequence of the enzyme are disclosed. The enzyme has an activity of lysing staphylococcus at pH 4-11, and can be a recombined soluble expression by gene construction in E. coli BL21 (DE3). The enzyme can be used as an antibiotic for treating staphylococcus infections in vivo.
(FR)La présente invention concerne une lyase qui peut tuer un staphylocoque et une utilisation correspondante, la séquence d'acides aminés et la séquence génique de codage de l'enzyme étant divulguées. L'enzyme possède une activité de lyse de staphylocoque à un pH de 4-11 et peut être une expression recombinée soluble par construction génique dans E. coli BL21 (DE3). L'enzyme peut être utilisée sous forme d'un antibiotique pour le traitement d'infections par staphylocoque in vivo.
(ZH)提供了一种能杀灭葡萄球菌的裂解酶及其应用,并公开了该酶的氨基酸序列和编码基因序列。该酶在pH4-11具有裂解葡萄球菌的活力,能在大肠杆菌BL21(DE3)中通过基因构建进行重组可溶性表达。该酶能用作治疗体内葡萄球菌感染的抗生素。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)