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Machine translation
1. (WO2016183741) PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/183741    International Application No.:    PCT/CN2015/079091
Publication Date: 24.11.2016 International Filing Date: 15.05.2015
IPC:
C07D 239/28 (2006.01), C07D 239/36 (2006.01), A61K 31/495 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/28 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway New Jersey 07065 (US).
SHEN, Dong-Ming [US/US]; (US) (US only).
QIAN, XiaoXia [US/US]; (US) (US only).
HARPER, Bart [US/US]; (US) (US only).
YANG, Meng [US/US]; (US) (US only).
WANG, Deping [US/US]; (US) (US only).
BO, Yingjian [CN/CN]; (CN) (US only)
Inventors: SHEN, Dong-Ming; (US).
QIAN, XiaoXia; (US).
HARPER, Bart; (US).
YANG, Meng; (US).
WANG, Deping; (US).
BO, Yingjian; (CN)
Agent: WU, FENG & ZHANG CO.; Room 305, Tower B, Beijing Aerospace Cpmiec Building No. 30, Haidian South Road, Haidian District, Beijing 100080 (CN)
Priority Data:
Title (EN) PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS
(FR) COMPOSÉS DE PYRIMIDINONE AMIDE EN TANT QU'INHIBITEURS DE PDE2
Abstract: front page image
(EN)The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
(FR)La présente invention concerne des composés de pyrimidinone amide qui sont utiles en tant qu'agents thérapeutiques pour le traitement de troubles du système nerveux central et/ou de troubles périphériques associés à la phosphodiestérase 2 (PDE2). La présente invention concerne également l'utilisation desdits composés pour le traitement de troubles neurologiques et psychiatriques, tels que la schizophrénie, la psychose, la maladie d'Alzeimer, les troubles cognitifs, l'anxiété, la dépression, les migraines ou la maladie de Huntington, la maladie de Parkinson, la démence associée à la maladie de Parkinson (DMP), et autres maladies associées à une hypofonction striatale ou à un dysfonctionnement ganglionnaire basal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)