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1. (WO2016183568) WATER SOLUBLE MICELLAR DRUG DELIVERY AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/183568    International Application No.:    PCT/US2016/032662
Publication Date: 17.11.2016 International Filing Date: 16.05.2016
IPC:
A61K 47/48 (2006.01), A61K 31/12 (2006.01), A61K 31/337 (2006.01), A61K 31/437 (2006.01)
Applicants: WAYNE STATE UNIVERSITY [US/US]; 5057 Woodward Ave. Suite 6400 Detroit, MI 48202 (US).
IYER, Arun, K [US/US]; (US)
Inventors: IYER, Arun, K; (US)
Agent: GOULD, Weston, R.; (US)
Priority Data:
62/161,428 14.05.2015 US
Title (EN) WATER SOLUBLE MICELLAR DRUG DELIVERY AGENTS
(FR) AGENTS D'ADMINISTRATION DE MÉDICAMENTS MICELLAIRES SOLUBLES DANS L'EAU
Abstract: front page image
(EN)A composition for targeted delivery of a therapeutic agent is provided herein, the composition including poly(styrene-co-maleic acid) (SMA) covalently conjugated to hyaluronic acid (HA). The HA-SMA composition optionally forms a micelle for targeted delivery of a therapeutic agent. Also provided herein is a method of treating a condition by administering a therapeutically-effective amount of a composition including HA-SMA conjugate and a non-covalently associated therapeutic agent, optionally further including curcumin difluorinated (CDF) or other therapeutic agent.
(FR)L'invention concerne une composition pour l'administration ciblée d'un agent thérapeutique, la composition comprenant du poly(styrène-co-acide maléique) (SMA) conjugué de manière covalente à l'acide hyaluronique (HA). La composition HA-SMA forme éventuellement une micelle pour l'administration ciblée d'un agent thérapeutique. L'invention concerne également une méthode de traitement d'une affection par l'administration d'une quantité thérapeutiquement efficace d'une composition comprenant le conjugué HA-SMA et un agent thérapeutique associé de manière non covalente, comprenant éventuellement en outre de la curcumine difluorée (CDF) ou un autre agent thérapeutique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)