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1. WO2016183479 - VARIANTS OF ADRENOMEDULLIN AND CALCITONIN GENE-RELATED PEPTIDE AND METHODS OF USE

Publication Number WO/2016/183479
Publication Date 17.11.2016
International Application No. PCT/US2016/032444
International Filing Date 13.05.2016
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 14/57527
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
57527Calcitonin gene related peptide
C07K 14/585
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
585Calcitonins
Applicants
  • THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA [US]/[US]
Inventors
  • PIOSZAK, Augen
Agents
  • HESTER, Kathryn L.
Priority Data
62/160,89913.05.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VARIANTS OF ADRENOMEDULLIN AND CALCITONIN GENE-RELATED PEPTIDE AND METHODS OF USE
(FR) VARIANTS DE L'ADRÉNOMÉDULLINE ET DU PEPTIDE LIÉ AU GÈNE DE LA CALCITONINE ET PROCÉDÉS POUR LEUR UTILISATION
Abstract
(EN)
Variant peptides of calcitonin gene-related peptide alpha (αCGRP), calcitonin gene-related peptide beta (βCGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high binding affinity and agonistic or antagonistic activity for at least one receptor complex of CLR:RAMP1, CLR:RAMP2, and CLR:RAMP3. Also disclosed are methods of use of the variant peptides in therapeutic treatments.
(FR)
L'invention concerne des peptides variants du peptide alpha lié au gène de la calcitonine (αCGRP), du peptide bêta lié au gène de la calcitonine (βCGRP), et de l'adrénomédulline (AM), les peptides variants présentant une affinité de liaison élevée et une activité agoniste ou antagoniste pour au moins un complexe de récepteurs parmi CLR:RAMP1, CLR:RAMP2, et CLR:RAMP3. L'invention concerne également des procédés d'utilisation des peptides variants dans des traitements thérapeutiques.
Also published as
Latest bibliographic data on file with the International Bureau