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1. (WO2016183280) TREATMENT OF BETA-THALASSEMIA USING ACTRII LIGAND TRAPS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/183280    International Application No.:    PCT/US2016/031999
Publication Date: 17.11.2016 International Filing Date: 12.05.2016
IPC:
A61K 38/18 (2006.01), A61P 7/00 (2006.01), A61P 7/06 (2006.01)
Applicants: CELGENE CORPORATION [US/US]; 86 Morris Avenue Summit, NJ 07901 (US).
ACCELERON PHARMA INC. [US/US]; 128 Sidney Street Cambridge, MA 02139 (US)
Inventors: ATTIE, Kenneth, M.; (US).
LAADEM, Abderrahmane; (US).
CHOPRA, Rajesh; (US).
BACKSTROM, Jay; (US)
Agent: MARTINEK, Sebastian; (US)
Priority Data:
62/161,136 13.05.2015 US
62/173,836 10.06.2015 US
62/243,457 19.10.2015 US
Title (EN) TREATMENT OF BETA-THALASSEMIA USING ACTRII LIGAND TRAPS
(FR) TRAITEMENT DE LA BETA-THALASSEMIA À L'AIDE DE PIÈGES À LIGAND ACTRII
Abstract: front page image
(EN)Provided herein are methods of treating beta-thalassemia by subcutaneous administration of about 0.8 mg/kg of an ActRII signaling inhibitor. Also provided herein are methods of adjusting the dose of the ActRII signaling inhibitor administered to the subject.
(FR)La présente invention concerne des méthodes de traitement de la bêta-thalassémie par administration sous-cutanée d'environ 0,8 mg/kg d'un inhibiteur de signalisation ActRII. L'invention concerne également des méthodes d'ajustement de la dose de l'inhibiteur de signalisation ActRII administré au sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)