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1. WO2016183244 - METHODS FOR TREATMENT OF OPIOID DEPENDENCY AND WITHDRAWAL USING NORIBOGAINE

Publication Number WO/2016/183244
Publication Date 17.11.2016
International Application No. PCT/US2016/031932
International Filing Date 11.05.2016
IPC
A61K 31/407 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61K 31/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 25/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
36Opioid-abuse
CPC
A61K 31/485
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/6615
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion ; or mevinphos
6615Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 25/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
36Opioid-abuse
Applicants
  • DEMERX, INC. [US]/[US]
Inventors
  • WEIS, Holger
Agents
  • MORLEY, Marc T.
Priority Data
62/159,90511.05.2015US
62/165,85322.05.2015US
62/180,57916.06.2015US
62/247,13027.10.2015US
62/260,18225.11.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATMENT OF OPIOID DEPENDENCY AND WITHDRAWAL USING NORIBOGAINE
(FR) PROCÉDÉS DE TRAITEMENT DE LA DÉPENDANCE AUX OPIOÏDES ET DES SYMPTÔMES DE SEVRAGE EN UTILISANT DE LA NORIBOGAÏNE
Abstract
(EN)
This disclosure is directed to a method of treating dependency on an opioid drug, including acute and post-acute withdrawal symptoms, comprising treating an opioid-dependent patient with noribogaine, noribogaine derivative, or pharmaceutically acceptable salt or solvate thereof with a multi-dose regimen and optionally an opioid antagonist.
(FR)
La présente invention concerne un procédé de traitement de la dépendance à un médicament opioïde, y compris les symptômes de sevrage aigus et post-aigus, consistant à traiter un patient dépendant aux substances opioïdes avec de la noribogaïne, un dérivé de la noribogaïne, ou un sel ou solvate de la noribogaïne pharmaceutiquement acceptable selon un schéma à doses multiples et éventuellement un antagoniste des récepteurs opioïdes.
Also published as
Latest bibliographic data on file with the International Bureau