Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2016182984) DISULFIDE-LINKED REVERSIBLE TERMINATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/182984 International Application No.: PCT/US2016/031416
Publication Date: 17.11.2016 International Filing Date: 09.05.2016
IPC:
C07H 19/073 (2006.01) ,C07H 19/10 (2006.01) ,C07H 19/173 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
073
with 2-deoxyribosyl as the saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
173
with 2-deoxyribosyl as the saccharide radical
Applicants:
JAIN, Moti [IN/US]; US (US)
HOFF, Kendall [US/US]; US (US)
MCGALL, Glenn [CA/US]; US (US)
ZHOU, Wei [US/US]; US (US)
CENTRILLION TECHNOLOGY HOLDINGS CORPORATION; Maples Corporate Services Limited P.O. Box 309, Ugland House Grand Cayman, Cayman Islands, KY1-1104, KY
Inventors:
JAIN, Moti; US
HOFF, Kendall; US
MCGALL, Glenn; US
ZHOU, Wei; US
Agent:
TIAN, Feng; US
Priority Data:
62/159,01708.05.2015US
Title (EN) DISULFIDE-LINKED REVERSIBLE TERMINATORS
(FR) TERMINATEURS RÉVERSIBLES À LIAISON DISULFURE
Abstract:
(EN) The present disclosure provides methods of sequencing polynucleotides and compounds, compositions useful for sequencing of polynucleotides. The chemical compounds include nucleotides and their analogs which possess a sugar moiety comprising a cleavable chemical group capping the 3'-OH group and a base that is attached to a detectable label through a cleavable linker comprising a disulfide bond. In addition, both the disulfide bond and the cleavable chemical group are cleavable by a chemical reagent. Furthermore, after the disulfide bond is cleaved by the chemical reagent, there is no free thiol group linked to the base of the nucleotides.
(FR) La présente invention concerne des procédés de séquençage de polynucléotides, ainsi que des composés et des compositions utiles pour le séquençage de polynucléotides. Les composés chimiques comportent des nucléotides et leurs analogues qui possèdent un fragment sucre comprenant un groupe chimique clivable, qui coiffe le groupe OH au niveau de l'extrémité 3', et une base qui est fixée à un marqueur détectable par le biais d'un groupe de liaison clivable comprenant une liaison disulfure. De plus, la liaison disulfure et le groupe chimique clivable peuvent être clivés par un réactif chimique. En outre, après clivage de la liaison disulfure par le réactif chimique, il ne reste pas de groupe thiol libre lié à la base des nucléotides.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)