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1. (WO2016182399) PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CHRONIC OBSTRUCTIVE LUNG DISEASE CONTAINING, AS ACTIVE INGREDIENT, MAGNOLIAE FLOS EXTRACT, FRACTION, OR ACTIVE FRACTION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/182399    International Application No.:    PCT/KR2016/005113
Publication Date: 17.11.2016 International Filing Date: 13.05.2016
IPC:
A61K 36/575 (2006.01)
Applicants: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 125, Gwahak-ro, Yuseong-gu, Daejeon 34141 (KR)
Inventors: OH, Sei-Ryang; (KR).
AHN, Kyung Seop; (KR).
LEE, Su Ui; (KR).
RYU, Hyung Won; (KR).
KIM, Doo-Young; (KR).
LEE, Hyeong Kyu; (KR).
KWON, Ok-Kyoung; (KR).
KIM, Jung Hee; (KR).
LEE, Hyun-Jun; (KR).
SHIN, In-Sik; (KR)
Agent: LEE, Won Hee; 8th Fl., Sung-ji Heights II 147, Teheran-ro, Gangnam-gu Seoul 06132 (KR)
Priority Data:
10-2015-0066621 13.05.2015 KR
Title (EN) PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CHRONIC OBSTRUCTIVE LUNG DISEASE CONTAINING, AS ACTIVE INGREDIENT, MAGNOLIAE FLOS EXTRACT, FRACTION, OR ACTIVE FRACTION THEREOF
(FR) COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION ET LE TRAITEMENT DE LA MALADIE PULMONAIRE OBSTRUCTIVE CHRONIQUE CONTENANT, COMME PRINCIPE ACTIF, UN EXTRAIT, UNE FRACTION OU UNE FRACTION ACTIVE DE FLOS MAGNOLIAE
(KO) 신이 추출물, 분획물 또는 이의 활성분획물을 유효성분으로 함유하는 만성 폐쇄성 폐질환 예방 및 치료용 약학적 조성물
Abstract: front page image
(EN)The present invention relates to a pharmaceutical composition for preventing or treating chronic obstructive lung disease, the composition containing, as an active ingredient, any one of a Magnoliae flos extract, a fraction thereof obtained by fractionation using an organic solvent, an active fraction, or a compound separated therefrom. It was verified that the Magnoliae flos extract, the fraction thereof obtained by fractionation using an organic solvent, the active fraction, or the compound separated therefrom, can be used to treat chronic obstructive lung disease by inhibiting the TNF-α-induced MUC5AC expression or promoter activity in human lung cancer mucosal cells (H292), suppressing the number of inflammatory cells in the bronchoalveolar lavage fluid of a chronic obstructive lung disease mouse model, inhibiting the generation of reactive oxygen species, and reducing cytokines. Therefore, the Magnoliae flos extract, the fraction thereof obtained by fractionation using an organic solvent, the active fraction, or the compound separated therefrom, of the present invention, can be favorably used as a pharmaceutical composition for preventing or treating chronic obstructive lung disease.
(FR)La présente invention concerne une composition pharmaceutique pour prévenir ou traiter une maladie pulmonaire obstructive chronique, la composition contenant, en tant que principe actif, l'un quelconque des éléments suivants parmi un extrait de Magnoliae flos, sa fraction obtenue par fractionnement à l'aide d'un solvant organique, sa fraction active, ou un composé séparé de celui-ci. Il a été vérifié que l'extrait de flos Magnoliae, sa fraction obtenue par fractionnement à l'aide d'un solvant organique, sa fraction active, ou le composé séparé de celui-ci peuvent être utilisés pour traiter une maladie pulmonaire obstructive chronique par l'inhibition de l'expression de MUC5AC induite par TNF-alpha ou l'activité de promoteurs dans des cellules des muqueuses du cancer du poumon chez l'Homme (H292), la suppression du nombre de cellules inflammatoires dans le fluide de lavage broncho-alvéolaire d'un modèle de souris atteinte de maladie pulmonaire obstructive chronique, l'inhibition de la génération d'espèces réactives de l'oxygène, et la réduction des cytokines. Par conséquent, l'extrait de flos Magnoliae, sa fraction obtenue par fractionnement à l'aide d'un solvant organique, sa fraction active, ou le composé séparé de celui-ci, de la présente invention, peuvent être favorablement utilisés en tant que composition pharmaceutique pour prévenir ou traiter une maladie pulmonaire obstructive chronique.
(KO)본 발명은 신이(Magnoliae flos) 추출물, 이의 유기용매를 이용하여 분획한 분획물, 활성 분획물, 또는 이로부터 분리한 화합물 중 어느 하나를 유효성분으로 함유하는 만성폐쇄성 폐질환 예방 또는 치료용 약학적 조성물에 관한 것으로, 신이 추출물, 이의 유기용매를 이용하여 분획한 분획물, 활성 분획물, 또는 이로부터 분리한 화합물이 인간 폐암점막세포 (H292) 세포에서 TNF-α에 의해 유도된 MUC5AC의 발현 또는 프로모터 활성을 억제하고, 만성폐쇄성 폐질환 마우스 모델의 기관지폐포세척액에서 염증세포의 수를 억제하고, 활성산소족의 생성을 억제하며, 사이토카인을 감소시킴으로써 만성폐쇄성 폐질환의 치료에 사용할 수 있음을 확인하였으므로, 본 발명의 신이 추출물, 이의 유기용매를 아용하여 분획한 분획물, 활성 분획물, 또는 이로부터 분리한 화합물은 만성폐쇄성 폐질환 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)