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1. (WO2016182311) COMPOSITION FOR CANCER CELL SENSITIZATION CONTAINING AS ACTIVE INGREDIENT SUBSTANCE INHIBITING EXPRESSION OF ONCOGENE OF HPV VIRUS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/182311    International Application No.:    PCT/KR2016/004867
Publication Date: 17.11.2016 International Filing Date: 10.05.2016
IPC:
A61K 48/00 (2006.01), A61K 31/713 (2006.01), A61K 41/00 (2006.01)
Applicants: ABION INC. [KR/KR]; (Gaepo-dong) room 202, Changwon Bldg., 5, Gaepo-ro 34-gil, Gangnam-gu, Seoul 06309 (KR)
Inventors: SHIN, Young Kee; (KR).
KIM, Young Deug; (KR).
JUNG, Hun Soon; (KR).
KIM, Deuk Ae; (KR).
HA, Tae Kyung; (KR)
Agent: LEE, Hee Sook; Siwon Intellectual Property Firm (JS Building, Yeoksam-dong) 9th Fl., 11, Teheran-ro 33 gil, Gangnam-gu, Seoul 06141 (KR)
Priority Data:
10-2015-0066218 12.05.2015 KR
Title (EN) COMPOSITION FOR CANCER CELL SENSITIZATION CONTAINING AS ACTIVE INGREDIENT SUBSTANCE INHIBITING EXPRESSION OF ONCOGENE OF HPV VIRUS
(FR) COMPOSITION PERMETTANT LA SENSIBILISATION DE CELLULES CANCÉREUSES CONTENANT EN TANT QUE PRINCIPE ACTIF UNE SUBSTANCE INHIBANT L'EXPRESSION D'ONCOGÈNES DE PAPILLOMAVIRUS
(KO) HPV 바이러스의 발암 유전자 발현 저해물질을 유효성분으로 포함하는 암세포 감작용 조성물
Abstract: front page image
(EN)The present invention relates to a composition for cancer cell sensitization containing as an active ingredient a substance inhibiting the expression of an oncogene of a HPV virus, and more specifically, to a composition for radiosensitization which is used for the treatment of cancer induced by HPV infection and contains as an active ingredient oligonucleotide having any one nucleic acid sequence selected from the group consisting of sequence numbers 1 to 10. The oligonucleotide of the present invention inhibits the expressions of E6 and E7 which are HPV virus oncoproteins, thereby inhibiting the proliferation of tumor cells, and enhances the sensitivity of tumor cells to radiation, thereby exhibiting an excellent effect as a sensitizer that can maximize the cell death effect.
(FR)La présente invention concerne une composition permettant la sensibilisation de cellules cancéreuses, contenant en tant que principe actif une substance inhibant l'expression d'oncogènes de papillomavirus (HPV), et plus spécifiquement, une composition pour la radiosensibilisation utilisée lors du traitement de cancers induits par une infection à HPV et contenant en tant que principe actif un oligonucléotide possédant une quelconque séquence d'acide nucléique sélectionnée au sein du groupe constitué par les séquences numérotées de 1 à 10. L'oligonucléotide de la présente invention inhibe l'expression de E6 et E7, lesquels sont des oncoprotéines des virus HPV, inhibant ainsi la prolifération des cellules tumorales, et augmente la sensibilité des cellules tumorales à l'irradiation, présentant de ce fait un excellent effet en tant que sensibilisateur pouvant maximiser l'effet de mort cellulaire.
(KO)본 발명은 HPV 바이러스의 발암 유전자 발현 저해물질을 유효성분으로 포함 하는 암세포 감작용 조성물에 관한 것으로, 보다 상세하게는 서열번호 1 내지 10으 로 이루어진 군에서 선택되는 어느 하나의 핵산 서열을 갖는 올리고뉴클레오티드를 유효성분으로 포함하며, HPV 감염에 의해 유발된 암 치료에 이용되는 방사선 감작 용 조성물에 관한 것이다. 본 발명의 올리고뉴클레오티드는 HPV 바이러스의 발암성 단백질인 E6 및 E7 의 발현을 저해하여 종양세포의 증식을 억제하며, 방사선에 대한 종양세포의 민감 도를 증진시켜 세포사멸 효과를 극대화할 수 있는 감작제로서 우수한 효과가 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)