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1. (WO2016182258) PHARMACEUTICAL COMPOSITION HAVING IMPROVED STABILITY AND SKIN PENETRATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/182258    International Application No.:    PCT/KR2016/004688
Publication Date: 17.11.2016 International Filing Date: 04.05.2016
IPC:
A61K 31/59 (2006.01), A61K 31/573 (2006.01), A61K 31/01 (2006.01), A61K 9/06 (2006.01)
Applicants: DONGKOO BIO&PHARMA CO.,LTD [KR/KR]; 222 Gochuk-ro, Guro-gu Seoul Seoul 08228 (KR)
Inventors: KIM, Yun Sik; (KR).
CHOO, Eui Jin; (KR).
HWANG, Kyu Hyeon; (KR).
LIM, Yoo Jin; (KR).
LEE, Hwan Hyuk; (KR).
CHOI, Sung Hoon; (KR)
Agent: SEO, Keunbok; (KR)
Priority Data:
10-2015-0064860 08.05.2015 KR
Title (EN) PHARMACEUTICAL COMPOSITION HAVING IMPROVED STABILITY AND SKIN PENETRATION
(FR) COMPOSITION PHARMACEUTIQUE PRÉSENTANT UNE STABILITÉ ET UNE PÉNÉTRATION CUTANÉE AMÉLIORÉES
(KO) 안정성과 피부투과율이 향상된 약학 조성물
Abstract: front page image
(EN)The present invention relates to a pharmaceutical composition for local skin, which, while containing at least one vitamin D or vitamin D homologue and at least one corticosteroid, has a reduction in stability deterioration due to a mutual reaction and an improvement in skin penetration. The stabilized composition containing at least one vitamin D or vitamin D homologue and at least one corticosteroid, of the present invention, solves problems of reducing contents and deteriorating pharmaceutical effects, caused by a mutual reaction occurring between the active ingredients, thereby obtaining not only effects of promoting appearance stability and content stability of a medical product but also an effect of reducing side effects caused by the generation of impurities. In addition, the use of at least one skin penetrating agent selected from C12-24 straight-chain alkanols and squalene leads to an improvement in skin penetration, thereby expecting a rapid therapeutic effect.
(FR)La présente invention concerne une composition pharmaceutique pour peau locale qui, tout en contenant au moins une vitamine D ou un homologue de vitamine D et au moins un corticostéroïde, présente une diminution de la détérioration de la stabilité due à une réaction mutuelle et une amélioration de la pénétration cutanée. La composition stabilisée selon la présente invention, contenant au moins une vitamine D ou un homologue de vitamine D et au moins un corticostéroïde, résout les problèmes de réduction de la teneur et de détérioration des effets pharmaceutiques, provoqués par une réaction mutuelle se produisant entre les principes actifs, ce qui permet d'obtenir non seulement des effets de promotion de la stabilité de l'apparence et de la stabilité de la teneur d'un produit médical, mais également un effet de réduction des effets secondaires provoqués par la production d'impuretés. En outre, l'utilisation d'au moins un agent de pénétration cutanée choisi parmi les alcanols à chaîne droite C12-24 et le squalène conduit à une amélioration de la pénétration cutanée, ce qui laisse escompter un effet thérapeutique rapide.
(KO)본 발명은 하나 이상의 비타민D 또는 비타민 D 동족체 및 하나이상의 코르티코스테로이드를 함유하면서, 상호 간의 반응에 의하여 안정성이 저하되는 것을 개선하고 피부투과율이 향상된 국소 피부용 약학 조성물에 관한 것이다. 본 발명의 하나 이상의 비타민D 또는 비타민 D 동족체 및 하나 이상의 코르티코스테로이드를 함유하는 안정화된 조성물은 상기 유효성분 사이에 발생하는 상호 반응에 의한 함량 저하 및 약효 저하의 문제를 해결하여 의약품의 성상 안정성, 함량 안정성의 증진 효과 뿐만 아니라, 불순물 생성으로 인한 부작용도 경감할 수 있는 효과를 얻을 수 있다. 또한 직쇄 C12-24 알칸올, 스쿠알란에서 선택되는 하나 또는 하나 이상의 피부 투과제를 사용하여 피부 투과율이 향상되어 빠른 치료효과를 기대할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)