WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016181990) CRYSTALS OF AZABICYCLIC COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/181990    International Application No.:    PCT/JP2016/063989
Publication Date: 17.11.2016 International Filing Date: 11.05.2016
IPC:
C07D 471/04 (2006.01), A61K 31/4439 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01)
Applicants: TAIHO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-27, Kandanishiki-cho, Chiyoda-ku, Tokyo 1018444 (JP)
Inventors: UNO, Takao; (JP)
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Sawanotsuru Ningyocho Bldg., 1-3-8, Nihonbashi Ningyocho, Chuo-ku, Tokyo 1030013 (JP)
Priority Data:
2015-097521 12.05.2015 JP
Title (EN) CRYSTALS OF AZABICYCLIC COMPOUND
(FR) CRISTAUX DE COMPOSÉ AZABICYCLIQUE
(JA) アザ二環式化合物の結晶
Abstract: front page image
(EN)Provided are crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are stable and have excellent oral absorbability. The crystals are II-form crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are characterized by giving an X-ray powder diffraction spectrum which has characteristic peaks at at least three diffraction angles (2θ±0.2º) selected from among 7.7º, 8.0º, 11.1º, 12.5º, 12.9º, 15.2º, 15.8º, 17.2º, 19.0º, 22.5º, 26.1º, and 27.4º.
(FR)Cette invention concerne des cristaux de 3-éthyl-4-{3-isopropyl-4-(4-(1-méthyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide qui sont stables et ont une excellente absorbabilité orale. Les cristaux sont des cristaux de forme II de 3-éthyl-4-{3-isopropyl-4-(4-(1-méthyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide qui sont caractérisés en ce qu'ils génèrent un spectre de diffraction des rayons X sur poudre qui comporte des pics caractéristiques à au moins trois angles de diffraction (2θ ± 0,2°) choisis parmi 7,7°, 8,0°, 11,1°, 12,5°, 12,9°, 15,2°, 15,8°, 17,2°, 19,0°, 22,5°, 26,1°, et 27,4º.
(JA) 3-エチル-4-{3-イソプロピル-4-(4-(1-メチル-1H-ピラゾール-4-イル)-1H-イミダゾ-ル-1-イル)-1H-ピラゾロ[3,4-b]ピリジン-1-イル}ベンズアミドの安定で経口吸収性に優れた結晶を提供する。 粉末X線回折スペクトルにおいて、回折角(2θ±0.2°)が、7.7゜、8.0゜、11.1゜、12.5゜、12.9゜、15.2゜、15.8゜、17.2゜、19.0゜、22.5゜、26.1゜、及び27.4゜から選択される少なくとも3つ以上の特徴的なピークを有することを特徴とする、3-エチル-4-{3-イソプロピル-4-(4-(1-メチル-1H-ピラゾール-4-イル)-1H-イミダゾ-ル-1-イル)-1H-ピラゾロ[3,4-b]ピリジン-1-イル}ベンズアミドのII型結晶。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)