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1. (WO2016181313) A PROCESS FOR THE PREPARATION OF SOFOSBUVIR INTERMEDIATES & ITS POLYMORPH
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2016/181313 International Application No.: PCT/IB2016/052684
Publication Date: 17.11.2016 International Filing Date: 11.05.2016
IPC:
C07F 9/24 (2006.01)
Applicants: LUPIN LIMITED[IN/IN]; Kalpataru Inspire 3rd Floor, Off Western Express Highway Santacruz (East) Mumbai 400 055, IN
Inventors: SINGH, Girij, Pal; IN
SRIVASTAVA, Dhananjai; IN
MEHARE, Kishor, Gulabrao; IN
MALIK, Vineet; IN
DEOKAR, Sharad, Chandrabhan; IN
DANGE, Abhijeet, Avinash; IN
Agent: MAJUMDAR, Subhatosh; IN
GANGULI, Dr., Sanchita; IN
SEN, Abhishek; IN
VENKATESH, Mythili; IN
MAJUMDAR, Amrita; IN
KUNDU, Subarna; IN
CHAUBEY, Priyanka; IN
Priority Data:
1857/MUM/201511.05.2015IN
Title (EN) A PROCESS FOR THE PREPARATION OF SOFOSBUVIR INTERMEDIATES & ITS POLYMORPH
(FR) PROCÉDÉ POUR LA PRÉPARATION D'INTERMÉDIAIRES SOFOSBUVIR ET LEUR FORME POLYMORPHE
Abstract: front page image
(EN) The present invention provides a novel process for preparation N-[(2,3,4,5,6- Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester (formula 2) and resolving the formula 2 in the presence base to form N-[(S)-(2,3,4,5,6- Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester (formula 2').
(FR) La présente invention concerne un nouveau procédé de préparation de N- [(2,3,4,5,6-Pentafluorophénoxy) phénoxyphosphinyl]-L-alanine 1-méthyléthyle ester (formule2) et la résolution de la formule 2 en présence d'une base pour former le N- [(S)- (2,3,4,5,6-Pentafluorophénoxy) phénoxyphosphinyl]-L-alanine 1-méthyléthyle ester (formule 2').
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)