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1. WO2016181275 - POLYMORPH FORMS OF PYRROLIDINE-2,5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS

Publication Number WO/2016/181275
Publication Date 17.11.2016
International Application No. PCT/IB2016/052612
International Filing Date 06.05.2016
Chapter 2 Demand Filed 27.02.2017
IPC
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 31/404 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • PFIZER INC. [US]/[US]
  • ITEOS THERAPEUTICS [BE]/[BE]
Inventors
  • CAUWENBERGHS, Sandra
  • CROSIGNANI, Stefano
  • DRIESSENS, Gregory
  • FICHTNER, Michael W.
  • KEENE, Nandell
Agents
  • WALDRON, Roy F.
  • RUBIN, David A.
Priority Data
62/161,53414.05.2015US
62/253,47810.11.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMORPH FORMS OF PYRROLIDINE-2,5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS
(FR) FORMES POLYMORPHES DE DÉRIVÉS PYRROLIDINE -2,5-DIONE, COMPOSITIONS PHARMACEUTIQUES ET PROCÉDÉS POUR UNE UTILISATION EN TANT QU'INHIBITEURS DE IDO1
Abstract
(EN)
Two distinct crystalline forms of a 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione are provided. Also provided are the use of these polymorphs as IDO1 inhibitors and/or for the treatment and/or prevention of cancer and endometriosis.
(FR)
La présente invention concerne deux formes cristallines distinctes d'un 3- (5-fluoro -1 H-indol-3-yl) pyrrolidine -2,5-dione. L'invention concerne également l'utilisation de ces polymorphes en tant qu'inhibiteurs de IDO1 et/ou pour le traitement et/ou la prévention du cancer et l'endométriose.
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