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1. (WO2016180770) FUNCTIONAL CURE OF RETROVIRAL INFECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/180770    International Application No.:    PCT/EP2016/060314
Publication Date: 17.11.2016 International Filing Date: 09.05.2016
IPC:
A61K 31/00 (2006.01)
Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; KU Leuven R&D Waaistraat 6, bus 5105 3000 Leuven (BE)
Inventors: CHRIST, Frauke; (BE).
DEBYSER, Zeger; (BE).
GIJSBERS, Rik; (BE).
VRANCKX, Lenard; (BE)
Agent: PAEMEN, Liesbet; (BE)
Priority Data:
1507866.0 08.05.2015 GB
1507859.5 08.05.2015 GB
Title (EN) FUNCTIONAL CURE OF RETROVIRAL INFECTION
(FR) TRAITEMENT FONCTIONNEL D'UNE INFECTION RÉTROVIRALE
Abstract: front page image
(EN)The application relates to methods of curing retroviral infections, i.e. ensuring remission of retroviral infections, more particularly HIV infections, by administering a compound which is capable of binding to the LEDGF/p75 binding pocket of HIV-integrase and inhibiting LEDGF/p75-IN protein-protein interaction. The application further relates to the use of LEDGINs in retroviral gene therapy.
(FR)La présente invention concerne des procédés de traitement d'infections rétrovirales, c'est-à-dire permettant d'assurer la rémission d'infections rétrovirales, plus particulièrement d'infections par le VIH, par l'administration d'un composé qui est capable de se lier à la poche de liaison LEDGF/p75 de l'intégrase du VIH et d'inhiber l'interaction protéine-protéine LEDGF/p75-IN. L'invention concerne en outre l'utilisation de LEDGIN dans la thérapie génique rétrovirale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)