WO2016179554 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

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Publication Number WO/2016/179554

Publication Date 10.11.2016

International Application No. PCT/US2016/031335

International Filing Date 06.05.2016

IPC

CPC

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Applicants

CHDI FOUNDATION, INC. [US]/[US]

Inventors

DOMINGUEZ, Celia
MAILLARD, Michel C.
HAUGHAN, Alan F.
VAN DE POËL, Amanda
STOTT, Andrew J.
LUCKHURST, Christopher A.
SAVILLE-STONES, Elizabeth A.
WISHART, Grant
WALL, Michael
BRECCIA, Perla
JARVIS, Rebecca E.

Agents

TANNER, Lorna L.

Priority Data

62/158,363

07.05.2015

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

(FR) INHIBITEURS D'HISTONE DÉSACÉTYLASE, COMPOSITIONS ET MÉTHODES D'UTILISATION CORRESPONDANTES

Abstract

(EN) Provided are certain histone deacetylase (HDAC) inhibitors of Formula (I), compositions thereof, and methods of their use.

(FR) L'invention concerne certains inhibiteurs d'histone désacétylase (HDAC) de formule (I), des compositions de ceux-ci, et des méthodes d'utilisation de ceux-ci.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42	Oxazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425	Thiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42	Oxazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425	Thiazoles

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1. WO2016179554 - HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
271	Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02	not condensed with other rings
06	1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles