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1. (WO2016179194) LILRA3 AND METHOD OF USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/179194    International Application No.:    PCT/US2016/030609
Publication Date: 10.11.2016 International Filing Date: 03.05.2016
IPC:
C07K 16/28 (2006.01), C07K 14/00 (2006.01), A61K 39/00 (2006.01)
Applicants: JOUNCE THERAPEUTICS, INC. [US/US]; 1030 Massachusetts Avenue Cambridge, Massachusetts 02138 (US)
Inventors: PHENNICIE, Ryan; (US).
WONG, Jamie; (US)
Agent: DONAHUE, Brian, A.; (US)
Priority Data:
62/156,852 04.05.2015 US
62/157,908 06.05.2015 US
Title (EN) LILRA3 AND METHOD OF USING THE SAME
(FR) LILRA3 ET SON PROCÉDÉ D'UTILISATION
Abstract: front page image
(EN)Provided herein are embodiments relating to therapeutic applications of molecules that modulate the biological activity of LILRA3. In some embodiments, the molecules bind TIM-3. In some embodiments, modulation of the interaction of TIM-3 and LILRA3 stimulates the release of pro-inflammatory cytokines; e.g., myeloid-associated pro -inflammatory cytokines.
(FR)La présente invention concerne des modes de réalisation se rapportant à des applications thérapeutiques de molécules qui modulent l'activité biologique de LILRA3. Dans certains modes de réalisation, les molécules se lient à TIM-3. Dans certains modes de réalisation, la modulation de l'interaction de TIM-3 et de LILRA3 stimule la libération de cytokines pro-inflammatoires; par exemple, des cytokines pro-inflammatoires associées à des myéloïdes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)