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1. (WO2016179011) ANTIFOLATE CONJUGATES FOR TREATING INFLAMMATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/179011    International Application No.:    PCT/US2016/030150
Publication Date: 10.11.2016 International Filing Date: 29.04.2016
IPC:
A61K 31/517 (2006.01), A61K 47/48 (2006.01), C07D 487/04 (2006.01)
Applicants: ENDOCYTE, INC. [US/US]; 3000 Kent Avenue West Lafayette, Indiana 47906 (US)
Inventors: VLAHOV, Iontcho Radoslavov; (US).
LEAMON, Christopher Paul; (US).
YOU, Fei; (US).
LU, Yingjuan J.; (US).
KLEINDL, Paul Joseph; (US)
Agent: BALL, Rebecca L.; (US)
Priority Data:
62/155,805 01.05.2015 US
Title (EN) ANTIFOLATE CONJUGATES FOR TREATING INFLAMMATION
(FR) CONJUGUÉS D'ANTIFOLATES POUR LE TRAITEMENT DE L'INFLAMMATION
Abstract: front page image
(EN)The present invention relates to compositions and methods for use in targeted drug delivery. More particularly, the invention is directed to cell-surface receptor binding conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations and to methods and pharmaceutical compositions that use and include such conjugates.
(FR)La présente invention concerne des compositions et des méthodes destinées à être utilisées dans l'administration ciblée de médicaments. Plus particulièrement, l'invention concerne des conjugués de liaison au récepteur de surface cellulaire contenant des lieurs espaceurs hydrophiles destinés à être utilisés dans le traitement d'états pathologiques provoqués par des populations de cellules pathogènes ainsi que des méthodes et des compositions pharmaceutiques qui utilisent et comprennent de tels conjugués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)