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1. (WO2016179006) METHODS OF ISOLATING T CELLS AND T CELL RECEPTORS HAVING ANTIGENIC SPECIFICITY FOR A CANCER-SPECIFIC MUTATION FROM PERIPHERAL BLOOD
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/179006    International Application No.:    PCT/US2016/030137
Publication Date: 10.11.2016 International Filing Date: 29.04.2016
IPC:
C12N 5/0783 (2010.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660 (US)
Inventors: GROS, Alena; (US).
ROSENBERG, Steven A.; (US)
Agent: LAWLEY, Stephanie M.; (US)
Priority Data:
62/155,830 01.05.2015 US
Title (EN) METHODS OF ISOLATING T CELLS AND T CELL RECEPTORS HAVING ANTIGENIC SPECIFICITY FOR A CANCER-SPECIFIC MUTATION FROM PERIPHERAL BLOOD
(FR) PROCÉDÉS D'ISOLEMENT DE CELLULES T ET DE RÉCEPTEURS DES CELLULES T AYANT UNE SPÉCIFICITÉ ANTIGÉNIQUE POUR UNE MUTATION SPÉCIFIQUE AU CANCER DU SANG PÉRIPHÉRIQUE
Abstract: front page image
(EN)Disclosed are methods of isolating T cells and TCRs having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer.
(FR)L'invention concerne des procédés d'isolement de cellules T et de TCR ayant une spécificité antigénique pour une séquence d'acides aminés mutés codée par une mutation spécifique au cancer. L'invention concerne également des procédés associés de préparation d'une population de cellules, des populations de cellules, des TCR, des compositions pharmaceutiques, et des méthodes de traitement ou de prévention du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)