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1. (WO2016178532) PRODUCTION METHOD FOR EXOSOME COMPRISING TARGET PROTEIN, AND METHOD FOR TRANSFERRING TARGET PROTEIN INTO CYTOPLASM BY USING EXOSOME PRODUCED BY MEANS OF THE PRODUCTION METHOD
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/178532    International Application No.:    PCT/KR2016/004750
Publication Date: 10.11.2016 International Filing Date: 04.05.2016
Chapter 2 Demand Filed:    18.11.2016    
IPC:
C12N 15/85 (2006.01), C12N 15/62 (2006.01), C12N 5/078 (2010.01), C12N 5/09 (2010.01), C07K 16/28 (2006.01), C07K 19/00 (2006.01), A61K 47/48 (2006.01)
Applicants: CELLEX LIFE SCIENCES, INCORPORATED [KR/KR]; 193, Munji-ro, Yuseong-gu, Daejeon 34051 (KR)
Inventors: CHOI, Chulhee; (KR).
YIM, Nambin; (KR).
HEO, Won Do; (KR).
RYU, Seung-Wook; (KR).
CHOI, Hojun; (KR).
CHOI, Kyungsun; (KR)
Agent: LEE, Won Hee; 8th Fl., Sung-ji Heights II, 147, Teheran-ro, Gangnam-gu, Seoul 06132 (KR)
Priority Data:
10-2015-0062604 04.05.2015 KR
10-2015-0120934 27.08.2015 KR
Title (EN) PRODUCTION METHOD FOR EXOSOME COMPRISING TARGET PROTEIN, AND METHOD FOR TRANSFERRING TARGET PROTEIN INTO CYTOPLASM BY USING EXOSOME PRODUCED BY MEANS OF THE PRODUCTION METHOD
(FR) PROCÉDÉ DE PRODUCTION D'EXOSOME COMPRENANT UNE PROTÉINE CIBLE ET PROCÉDÉ DE TRANSFERT DE PROTÉINE CIBLE DANS LE CYTOPLASME À L'AIDE DE L'EXOSOME PRODUIT PAR LE PROCÉDÉ DE PRODUCTION
(KO) 목적 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 이용하여 목적 단백질을 세포질로 전달시키는 방법
Abstract: front page image
(EN)The present invention relates to a method for producing a large volume of an exosome comprising a target protein, to an exosome-producing vector that can be used in the exosome production, to an exosome comprising a target protein produced by means of the method, and to a method for transferring the target protein into cytoplasm by using the exosome which is produced. When using the production method for an exosome comprising the target protein provided by the present invention, the exosome comprising the target protein can be produced in high yield, and thus the present invention can be widely used in disease treatment using the exosome.
(FR)La présente invention concerne un procédé de production d'un grand volume d'un exosome comprenant une protéine cible, un vecteur producteur d'exosomes qui peut être utilisé dans la production d'exosomes, un exosome comprenant une protéine cible produite au moyen du procédé, et un procédé permettant de transférer la protéine cible dans le cytoplasme à l'aide de l'exosome qui est produit. Lors de l'utilisation du procédé de production d'un exosome comprenant la protéine cible fourni par la présente invention, l'exosome comprenant la protéine cible peut être produit avec un rendement élevé, et, par conséquent, la présente invention peut être largement utilisée dans le traitement de maladies à l'aide de l'exosome.
(KO)본 발명은 목적 단백질을 포함하는 엑소솜을 대량으로 제조하는 방법, 상기 엑소솜 제조에 사용될 수 있는 엑소솜 제조용 백터, 상기 방법으로 제조된 목적 단백질을 포함하는 엑소솜 및 제조된 엑소솜을 이용하여 목적 단백질을 세포질로 전달시키는 방법에 관한 것이다. 본 발명에서 제공하는 목적 단백질을 포함하는 엑소솜의 제조방법을 이용하면, 목적 단백질을 포함하는 엑소솜을 높은 수율로 제조할 수 있으므로, 상기 엑소솜을 이용한 질환의 치료에 널리 활용될 수 있을 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)