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1. (WO2016178493) TYNDALLIZED CLOSTRIDIUM BUTYRICUM HAVING EFFECT OF PREVENTING AND TREATING ARTHRITIS, AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/178493    International Application No.:    PCT/KR2016/004528
Publication Date: 10.11.2016 International Filing Date: 29.04.2016
IPC:
C12N 1/20 (2006.01), C12R 1/145 (2006.01)
Applicants: ILDONG PHARM CO., LTD. [KR/KR]; (Yangjae-dong ) 2, Baumoe-ro 27-gil Seocho-gu, Seoul 06752 (KR)
Inventors: LEE, Seung-Hun; (KR).
KIM, Min Gu; (KR).
KANG, Dae Jung; (KR).
KANG, Jae-Hoon; (KR)
Agent: LEE, Hee Sook; SIWON Intellectual Property Firm (JS Building, Yeoksam-dong) 9th Fl, 11, Teheran-ro 33 gil, Gangnam-gu, Seoul 06141 (KR)
Priority Data:
10-2015-0062300 01.05.2015 KR
Title (EN) TYNDALLIZED CLOSTRIDIUM BUTYRICUM HAVING EFFECT OF PREVENTING AND TREATING ARTHRITIS, AND USE THEREOF
(FR) CLOSTRIDIUM BUTYRICUM TYNDALLISÉ PRÉSENTANT UN EFFET DE PRÉVENTION ET DE TRAITEMENT DE L’ARTHRITE, ET UTILISATION CORRESPONDANTE
(KO) 관절염 예방 및 치료 효과를 갖는 틴달화 클로스트리디움 부티리쿰 및 이의 용도
Abstract: front page image
(EN)The present invention relates to tyndallized Clostridium butyricum having an effect of preventing and treating arthritis, and a use thereof and, more specifically, to: dead bacterial cells of tyndallized Clostridium butyricum IDCC 5101 contributing to the prevention of arthritis and the relief of symptoms by lowering the level of COX-2, which is an articular inflammation biomarker, and a tumor necrosis factor-α (TNF-α), which is an inflammatory cytokine; and a composition for preventing and treating arthritis, containing the same as an active ingredient. It is confirmed that dead bacterial cells of Clostridium butyricum IDCC 5101, according to the present invention, have an effect of preventing and treating arthritis by relieving, in a concentration-dependent manner, the symptoms of arthritis in arthritis animal models.
(FR)La présente invention concerne un Clostridium butyricum tyndallisé présentant un effet de prévention et de traitement de l'arthrite, et son utilisation et, plus spécifiquement : des cellules bactériennes mortes de Clostridium butyricum tyndallisé IDCC 5101 contribuant à la prévention de l'arthrite et au soulagement des symptômes en réduisant le niveau de COX-2, qui est un biomarqueur de l'inflammation articulaire, et le facteur de nécrose des tumeurs α (TNF-α), qui est une cytokine inflammatoire ; et une composition de prévention et de traitement de l'arthrite, le contenant en tant qu'ingrédient actif. Il est confirmé que les cellules bactériennes mortes de Clostridium butyricum IDCC 5101, selon la présente invention, présentent un effet de prévention et de traitement de l'arthrite en soulageant, d'une manière dépendant de la concentration, les symptômes de l'arthrite dans les modèles animaux de l'arthrite.
(KO)본 발명은 관절염 예방 및 치료 효과를 갖는 틴달화 클로스트리디움 부티리쿰 및 이의 용도에 관한 발명으로, 보다 상세하게는 관절염증의 바이오마커인 COX-2 및 염증성 싸이토카인인 tumor necrosis factor-α (TNF-α)의 수치를 낮춰 관절염을 예방하고 증상을 완화시키는데 기여하는 틴달화된 클로스트리디움 부티리쿰 IDCC 5101 사균체 및 이를 유효성분으로 포함하는 관절염 예방 및 치료용 조성물에 관한 것이다. 본 발명에 따른 클로스트리디움 부티리쿰 IDCC 5101 사균체는 관절염 동물모델에서 농도 의존적으로 관절염 증상을 완화시켜 관절염 예방 및 치료효과가 있음을 확인하였다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)