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1. WO2016177760 - PYRIDAZINE DERIVATIVES AS RORc MODULATORS

Publication Number WO/2016/177760
Publication Date 10.11.2016
International Application No. PCT/EP2016/059951
International Filing Date 04.05.2016
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
26
condensed with carbocyclic rings or ring systems
28
Cinnolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
502
ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C07D 237/28 (2006.01)
A61K 31/502 (2006.01)
A61P 17/06 (2006.01)
A61P 19/02 (2006.01)
A61P 37/00 (2006.01)
CPC
C07D 237/26
C07D 237/28
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (US)
Inventors
  • FAUBER, Benjamin; US
  • CRAWFORD, James J.; US
  • BRONNER, Sarah M.; US
  • BODIL VAN NIEL, Monique; GB
  • CRIDLAND, Andrew; GB
  • GANCIA, Emanuela; GB
  • HURLEY, Christopher; GB
  • KILLEN, Jonathan; GB
  • WARD, Stuart; GB
Agents
  • BERNARD, Guillaume; CH
Priority Data
62/156,57904.05.2015US
62/321,87213.04.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRIDAZINE DERIVATIVES AS RORc MODULATORS
(FR) DÉRIVÉS DE PYRIDAZINE UTILISÉS EN TANT QUE MODULATEURS DE RORC
Abstract
(EN)
Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
(FR)
La présente invention concerne des composés de formule (I) ou leurs sels pharmaceutiquement acceptables. Dans la formule (I), m, A, X, Y, Z, R1, R2, R3, R4 et R5 sont tels que définis dans la description. L'invention concerne également des procédés d'élaboration de ces composés, ainsi que des méthodes consistant à utiliser ces composés pour traiter des maladies inflammatoires telles que l'arthrite.
Also published as
Latest bibliographic data on file with the International Bureau