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1. (WO2016176450) TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/176450    International Application No.:    PCT/US2016/029781
Publication Date: 03.11.2016 International Filing Date: 28.04.2016
IPC:
C07D 403/04 (2006.01), C07D 207/44 (2006.01), A61K 31/401 (2006.01), A61K 31/4025 (2006.01), A61P 33/06 (2006.01)
Applicants: PORTLAND STATE UNIVERSITY [US/US]; P.O.Box 751-RSP Portland, OR 97207-0751 (US)
Inventors: KANCHARLA, Papireddy; (US).
KELLY, Jane, Xu; (US).
REYNOLDS, Kevin, A.; (US)
Agent: GARDNER, Gillian; (US)
Priority Data:
62/155,383 30.04.2015 US
Title (EN) TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES
(FR) TAMBJAMINES ET PRODIGININES FONCTIONNALISÉES À CYCLE B
Abstract: front page image
(EN)Embodiments of tambjamines and B-ring functionalized prodiginines are disclosed. Methods of synthesizing and using the disclosed compounds are also disclosed. Some embodiments of the disclosed compounds have antimalarial activity. Certain embodiments of the disclosed compounds have been shown to clear parasitemia in mice, and/or are curative in a single dose without toxicity.
(FR)L’invention concerne, selon des modes de réalisation, des tambjamines et des prodiginines fonctionnalisées à cycle B. L'invention concerne en outre des procédés de synthèse et d'utilisation des composés décrits. Certains modes de réalisation des composés décrits présentent une activité antipaludique. Certains modes de réalisation des composés décrits se sont avérés éliminer la parasitémie chez la souris, et/ou sont curatifs en une dose unique sans toxicité.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)