WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016176366) DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF HYPERAMMONEMIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/176366    International Application No.:    PCT/US2016/029623
Publication Date: 03.11.2016 International Filing Date: 27.04.2016
IPC:
G01N 33/48 (2006.01), G01N 33/50 (2006.01), G01N 33/52 (2006.01)
Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK [US/US]; Office of Technology Commercialization 2130 Mitchell Building College Park, MD 20742 (US).
CHILDREN'S NATIONAL MEDICAL CENTER [US/US]; 111 Michigan Avenue, NW Washington, DC 20010 (US)
Inventors: AYYUB, Omar, Bilal; (US).
BEHRENS, Adam, Michael; (US).
KOFINAS, Peter; (US).
SUMMAR, Marshall, Lynn; (US).
CABRERA-LUQUE, Juan, Manuel; (US).
CUNNINGHAM, Gary; (US)
Agent: ZURAWSKI, John, A.; (US)
Priority Data:
62/153,409 27.04.2015 US
Title (EN) DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF HYPERAMMONEMIA
(FR) DISPOSITIF ET PROCÉDÉS D'UTILISATION D'UN DISPOSITIF POUR LA DÉTECTION DE L'HYPERAMMONIÉMIE
Abstract: front page image
(EN)The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflunnated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care biosensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.
(FR)La présente invention concerne un biocapteur pouvant mesurer la concentration totale d'un ou de plusieurs ions ammoniac ou ammonium par l'utilisation de réactifs indophénol en présence d'un ionomère. Selon certains modes de réalisation, le biocapteur comprend une membrane perfluorée qui comprend un ionomère en contact avec un tampon alcalin dans un récipient conçu pour recevoir un échantillon, tel que du sang total. L'invention concerne également un procédé de détection ou de quantification de la concentration en ions ammoniac ou ammonium dans le sang total dans un biocapteur sur point d'intervention sans dépendre d'une chromatographie en phase gazeuse ou d'une quelconque mesure qui prend plus d'environ vingt minutes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)