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1. (WO2016175393) MARKERS FOR DIAGNOSING ANGIOSTENOSIS AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/175393    International Application No.:    PCT/KR2015/008642
Publication Date: 03.11.2016 International Filing Date: 19.08.2015
IPC:
G01N 33/68 (2006.01), C12Q 1/68 (2006.01)
Applicants: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY [KR/KR]; 1732, Deogyeong-daero, Giheung-gu Yongin-si, Gyeonggi-do 17104 (KR).
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR/KR]; 1, Gwanak-ro Gwanak-gu Seoul 08826 (KR).
GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 1342, Seongnam-daero, Sujeong-gu Seongnam-si Gyeonggi-do 13120 (KR).
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION [KR/KR]; Korea University, 145, Anam-ro Seongbuk-gu Seoul 02841 (KR)
Inventors: KIM, Kwang Pyo; (KR).
CHOI, Sung Hee; (KR).
LEE, Hoo Keun; (KR).
LEE, Sang Won; (KR)
Agent: SON, Min; (KR)
Priority Data:
10-2015-0061981 30.04.2015 KR
Title (EN) MARKERS FOR DIAGNOSING ANGIOSTENOSIS AND USE THEREOF
(FR) MARQUEURS POUR DIAGNOSTIQUER L'ANGIOSTÉNOSE ET LEUR UTILISATION
(KO) 혈관 협착 질환 진단용 마커 및 이의 용도
Abstract: front page image
(EN)Provided are: a composition for diagnosing non-diabetic angiostenosis, containing a preparation measuring the level of one or more proteins selected from the group consisting of poly (ADP-ribose) polymerase 4 (PARP4), vitamin D-binding protein (VDB), and laminin subunit beta-1 (LAMB1); a composition for diagnosing diabetic angiostenosis, containing a preparation measuring the level of one or more proteins selected from the group consisting of interferon regulatory factor 7 (IRF7), a dedicator of cytokinesis protein 2 (DOCK2), and a hemoglobin subunit beta (HBB); a kit for diagnosing angiostenosis, containing the composition for diagnosing diabetic angiostenosis; a method for providing information for diagnosing non-diabetic angiostenosis; and a method for providing information for diagnosing non-diabetic angiostenosis. The present invention provides a composition for diagnosing angiostenosis, so as to measure and compare the changing protein expression levels in non-diabetic or diabetic angiostenosis patients, thereby enabling early diagnosis of angiostenosis and a meaningful prediction or an identification of the degree of the disease. In addition, the diagnostic composition of the present invention enables non-invasive diagnosis, thereby enabling simple and valid early stage diagnosis of angiostenosis by using blood and urine testing and the like.
(FR)L'invention concerne : une composition pour diagnostiquer l'angiosténose non-diabétique, contenant une préparation mesurant le niveau d'une ou de plusieurs protéines choisies dans le groupe constitué de la poly (ADP-ribose) polymérase 4 (PARP4), de la protéine de liaison à la vitamine D (VDB), et de la sous-unité bêta-1 de la laminine (LAMB1) ; une composition pour diagnostiquer l'angiosténose diabétique, contenant une préparation mesurant le niveau d'une ou de plusieurs protéines choisies dans le groupe constitué du facteur de régulation de l'interféron 7 (IRF7), d'une dédicataire de la protéine de la cytocinèse 2 (DOCK2), et d'une sous-unité bêta de l'hémoglobine (HBB) ; un kit pour diagnostiquer l'angiosténose contenant la composition pour diagnostiquer l'angiosténose diabétique ; un procédé pour fournir des informations pour diagnostiquer l'angiosténose non-diabétique ; et un procédé pour fournir des informations pour diagnostiquer l'angiosténose non diabétique. La présente invention concerne une composition pour diagnostiquer l'angiosténose, de manière à mesurer et à comparer le changement des niveaux d'expression de protéines chez des patients atteints de l'angiosténose non diabétique ou diabétique, ce qui permet le diagnostic précoce de l'angiosténose et une prédiction ou une identification du degré de la maladie pertinentes. En outre, la composition de diagnostic de la présente invention permet un diagnostic non effractif, ce qui permet un diagnostic de stade précoce simple et valide de l'angiosténose par test du sang et de l'urine et analogues.
(KO)본 발명은 폴리 (ADP-리보스) 폴리머라제 4 (Poly (ADP-ribose) polymerase 4, PARP4), 비타민 D-결합 단백질 (Vitamin D-binding protein, VDB) 및 라미닌 서브유닛 베타-1 (Laminin subunit beta-1, LAMB1)으로 이루어진 군에서 선택되는 하나 이상의 단백질 수준을 측정하는 제제를 포함하는, 비당뇨병성 혈관 협착 질환 진단용 조성물, 인터페론 조절 인자 7 (Interferon regulatory factor 7, IRF7), 세포질 분열 단백질의 데디케이터 2 (Dedicator of cytokinesis protein 2, DOCK2), 및 헤모글로빈 서브유닛 베타 (Hemoglobin subunit beta, HBB)로 이루어진 군에서 선택되는 하나 이상의 단백질 수준을 측정하는 제제를 포함하는, 당뇨병성 혈관 협착 질환 진단용 조성물, 및 상기 조성물을 포함하는, 혈관 협착 질환 진단용 키트, 상기 비당뇨병성 혈관 협착 질환 진단을 위한 정보의 제공 방법 및 상기 비당뇨병성 혈관 협착 질환 진단을 위한 정보의 제공 방법을 제공한다. 본 발명은, 혈관 협착 질환 진단용 조성물을 제공함으로서, 비당뇨병성 또는 당뇨병성 혈관 협착 질환 환자에게서 발현이 변화하는 단백질의 발현 수준을 측정 및 비교함으로서, 혈관 협착 질환의 조기진단 및 질병 정도를 유의적으로 예측 또는 파악할 수 있다. 아울러, 본 발명의 진단용 조성물은 비침습성 진단을 가능하게 하여 혈액, 뇨 검사 등으로 간단하고 유효성 있는, 혈관 협착 질환의 초기 진단을 할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)