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Pub. No.:    WO/2016/174408    International Application No.:    PCT/GB2016/051164
Publication Date: 03.11.2016 International Filing Date: 26.04.2016
C07K 14/705 (2006.01), C07K 16/28 (2006.01), C12N 15/85 (2006.01)
Applicants: UCL BUSINESS PLC [GB/GB]; The Network Building 97 Tottenham Court Road London W1T 4TP (GB)
Inventors: PULÉ, Martin; (GB).
CORDOBA, Shaun; (GB)
Agent: WILLIAMS, Aylsa; (GB)
Priority Data:
1507104.6 27.04.2015 GB
Abstract: front page image
(EN)The present invention provides a nucleic acid construct comprising the following structure: A – X – B in which A and B are nucleic acid sequences encoding a first and a second polypeptide of interest (POI); and X is a nucleic acid sequence which encodes a cleavage site, wherein either the first or second POI is a transmembrane protein which comprises an intracellular retention signal.
(FR)La présente invention concerne une construction d'acide nucléique comprenant la structure suivante : A-X-B dans laquelle A et B sont des séquences d'acide nucléique codant pour un premier et un second polypeptide d'intérêt (POI); et X est une séquence d'acide nucléique qui code pour un site de clivage, le premier ou le deuxième polypeptide d'intérêt étant une protéine transmembranaire qui comprend un signal de rétention intracellulaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)