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1. (WO2016173682) CONJUGATE OF MONOMETHYL AURISTATIN F AND TRASTUZUMAB AND ITS USE FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/173682    International Application No.:    PCT/EP2015/074766
Publication Date: 03.11.2016 International Filing Date: 26.10.2015
IPC:
A61K 47/48 (2006.01), A61P 35/00 (2006.01)
Applicants: PIERRE FABRE MEDICAMENT [FR/FR]; 45, place Abel Gance F-92100 Boulogne-Billancourt (FR)
Inventors: GOETSCH, Liliane; (FR).
JOUHANNEAUD, Alexandra; (FR).
PEREZ, Michel; (FR)
Agent: REGIMBEAU; 20, rue de Chazelles F-75847 Paris Cedex 17 (FR)
Priority Data:
PCT/EP2015/059052 27.04.2015 EP
Title (EN) CONJUGATE OF MONOMETHYL AURISTATIN F AND TRASTUZUMAB AND ITS USE FOR THE TREATMENT OF CANCER
(FR) CONJUGUÉ DE MONOMÉTHYLE AURISTATINE F ET DE TRASTUZUMAB ET SON UTILISATION POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody consisting of the Trastuzumab, said antibody being conjugated to at least one drug consisting of a monomethyl auristatin F derivative. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.
(FR)La présente invention concerne un conjugué anticorps-médicament. Selon un aspect, l'invention concerne un conjugué anticorps-médicament comprenant un anticorps constitué de Trastuzumab, ledit anticorps étant conjugué à au moins un médicament constitué d'un dérivé de monométhyle auristatine F. L'invention concerne également un procédé de traitement et l'utilisation dudit conjugué anticorps-médicament pour le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)