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1. (WO2016173603) CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS AUTOLYSIN E, METHOD OF PRODUCING THE CRYSTAL AND ITS USE IN SCREENING METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/173603    International Application No.:    PCT/EP2015/000865
Publication Date: 03.11.2016 International Filing Date: 27.04.2015
IPC:
C12N 9/36 (2006.01), G06F 19/16 (2011.01), A61K 39/085 (2006.01)
Applicants: J. STEFAN INSTITUTE [SI/SI]; Jamova 39 1000 Ljubljana (SI)
Inventors: MIHELIČ, Marko; (SI).
RENKO, Miha; (SI).
TURK, Dusan; (SI)
Agent: BÖSL, Raphael; Isenbruck Bösl Hörschler LLP Prinzregentenstrasse 68 81675 München (DE)
Priority Data:
Title (EN) CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS AUTOLYSIN E, METHOD OF PRODUCING THE CRYSTAL AND ITS USE IN SCREENING METHODS
(FR) STRUCTURE CRISTALLINE D’AUTOLYSINE E DE STAPHYLOCOCCUS AUREUS, PROCÉDÉ DE PRODUCTION DU CRISTAL ET SON UTILISATION DANS LES PROCÉDÉS DE CRIBLAGE
Abstract: front page image
(EN)The invention concerns the determination and evaluation of the crystal structure of autolysin E (AtlE) of Staphylococcus aureus (S. aureus), or a crystallizable fragment of AtlE, a method for producing a crystal of AtlE and the respective crystallization kit, and its use in a method for screening an inhibitor of the N-acetylglucosaminidase activity of AtlE, for obtaining atomic spatial relationship data, and for identifying a binding compound of AtlE, e.g. by in silico screening.
(FR)La présente invention concerne la détermination et l'évaluation de la structure cristalline de l'autolysine E (AtlE) de Staphylococcus aureus (S. aureus), ou d'un fragment cristallisable d'AtlE, un procédé de production d'un cristal d'AtlE et la trousse de cristallisation respective, et son utilisation dans un procédé de criblage d'un inhibiteur de l'activité N-acétylglucosaminidase de l'AtlE, permettant l'obtention de données de relation atomique spatiale, et permettant l'identification d'un composé de liaison de l'AtlE, par exemple par criblage in silico.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)