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1. WO2016173504 - ACTINOBACILLUS PLEUROPNEUMONIAE RECOMBINANT TOXIN PROTEIN AND APPLICATION THEREOF

Publication Number WO/2016/173504
Publication Date 03.11.2016
International Application No. PCT/CN2016/080469
International Filing Date 28.04.2016
Chapter 2 Demand Filed 25.08.2016
IPC
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 14/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
36from Actinomyces; from Streptomyces (G)
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C07K 16/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12against material from bacteria
A61K 39/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A61K 2039/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/55505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55505Inorganic adjuvants
A61K 2039/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
575humoral response
A61K 2039/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
70Multivalent vaccine
A61K 39/102
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
102Pasteurellales, e.g. Actinobacillus; , Pasteurella; Haemophilus
Applicants
  • 金协国际实业有限公司 GOLDEN SCORPIO INTERNATIONAL CO., LTD. [CN]/[CN]
Inventors
  • 杨滢臻 YANG, Ying-Chen
  • 郭村勇 KUO, Tsun-Yung
Agents
  • 北京天平专利商标代理有限公司 WANG & ASSOCIATES
Priority Data
62/153,71128.04.2015US (Priority Withdrawn 18.10.2017)
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ACTINOBACILLUS PLEUROPNEUMONIAE RECOMBINANT TOXIN PROTEIN AND APPLICATION THEREOF
(FR) PROTÉINE RECOMBINANTE DE TOXINE D'ACTINOBACILLUS PLEUROPNEUMONIAE ET APPLICATION CORRESPONDANTE
(ZH) 猪胸膜肺炎放线杆菌重组毒素蛋白及其应用
Abstract
(EN)
The present invention provides an actinobacillus pleuropneumoniae recombinant toxin protein, comprising at least one antigenic determinant of an actinobacillus pleuropneumoniae toxin protein; and when there is a plurality of antigenic determinants, connexons can exist among the antigenic determinants. A recombinant protein may comprise at least one amino acid sequence of a complement fragmentation C3d, and connexons can exist between antigenic determinants and the amino acid sequences of the C3d. The present invention also provides a nucleotide sequence for encoding a protein, and an immune composition containing the protein.
(FR)
La présente invention concerne une protéine recombinante de toxine d'actinobacillus pleuropneumoniae, comprenant au moins un déterminant antigénique d'une protéine de toxine d'actinobacillus pleuropneumoniae ; et, lorsque les déterminants antigéniques sont multiples, des connexons peuvent être présents parmi les déterminants antigéniques. Une protéine de recombinaison peut comprendre au moins une séquence d'acides aminés de la fraction du complément C3d, et des connexons peuvent être présents entre les déterminants antigéniques et les séquences d'acides aminés du C3d. La présente invention concerne également une séquence nucléotidique codant pour une protéine, et une composition immunitaire contenant la protéine.
(ZH)
本发明提供了一种猪胸膜肺炎放线杆菌(Actinobacillus pleuropneumoniae)重组毒素蛋白,包括至少一个猪胸膜肺炎放线杆菌毒素蛋白的抗原决定位;当所述抗原决定位为复数个时,各抗原决定位之间可有连接子。所述重组蛋白可包含至少一个补体裂解片段C3d的氨基酸序列,且所述抗原决定位与C3d的氨基酸序列之间可有连接子。本发明还提供了编码所述蛋白的核苷酸序列,以及含有所述蛋白的免疫组合物。
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