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1. (WO2016173214) HSP90 INHIBITION PEPTIDE CONJUGATE AND APPLICATION THEREOF IN TREATING TUMOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/173214    International Application No.:    PCT/CN2015/091888
Publication Date: 03.11.2016 International Filing Date: 14.10.2015
IPC:
A61K 47/48 (2006.01), A61K 38/08 (2006.01), A61K 31/337 (2006.01), A61K 31/704 (2006.01), A61P 35/00 (2006.01)
Applicants: INSTITUTE OF BASIC MEDICAL SCIENCES, CHINESE ACADEMY OF MEDICAL SCIENCES [CN/CN]; 5 Dongdan San Tiao, Dongcheng District Beijing 100005 (CN)
Inventors: LIU, Yanyong; (CN).
YANG, Nan; (CN).
ZUO, Pingping; (CN)
Agent: BEIJING TECHSTONE INTELLECTUAL PROPERTY AGENCY LTD; Wisdom Plaza 203B, Xueyuan South Road No.38 Haidian District, Beijing 100082 (CN)
Priority Data:
201510203194.X 27.04.2015 CN
Title (EN) HSP90 INHIBITION PEPTIDE CONJUGATE AND APPLICATION THEREOF IN TREATING TUMOR
(FR) CONJUGUÉ PEPTIDIQUE INHIBITEUR DE HSP90 ET APPLICATION DE CE DERNIER DANS LE TRAITEMENT D'UNE TUMEUR
(ZH) HSP90抑制肽偶联物及其在肿瘤治疗中的应用
Abstract: front page image
(EN)A conjugate formed by a HSP90 inhibition peptide and cytotoxic agent via linker conjugation and usage thereof in preparing medicine for preventing and/or treating tumor. The conjugate has three anti-tumor effects including targeting delivery, chemistry treatment and tumor destruction, and can increase a drug capability of destroying the tumor. A reduction in relative dosage can obviously reduce the toxicity induced by accumulation of chemotherapy drugs.
(FR)L'invention porte sur un conjugué formé par un peptide inhibiteur de HSP90 et un agent cytotoxique par le biais d'une conjugaison de lieurs et sur son utilisation lors de la préparation d'un médicament destiné à prévenir et/ou à traiter une tumeur. Le conjugué présente trois effets anti-tumoraux comprenant le ciblage de l'administration, le traitement chimique et la destruction tumorale et peut augmenter la capacité du médicament à détruire la tumeur. Une réduction du dosage relatif peut de toute évidence réduire la toxicité induite par une accumulation de médicaments de chimiothérapie.
(ZH)一种由HSP90抑制肽与细胞毒性剂通过接头偶联形成的偶联物以及其在制备用于预防和/或治疗肿瘤的药物中的用途。所述偶联物具有靶向递送、化学治疗与促凋亡的三重抗肿瘤功效,能增强药物对肿瘤的杀伤能力,相应地减少用药量,可以明显减轻因化疗药物蓄积所引起的毒副作用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)