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1. (WO2016172795) MODULATING URACIL-DNA GLYCOSYLASE AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/172795    International Application No.:    PCT/CA2016/050486
Publication Date: 03.11.2016 International Filing Date: 27.04.2016
IPC:
A61K 38/16 (2006.01), A61K 31/395 (2006.01), A61K 35/76 (2015.01), A61K 38/15 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), C07D 225/06 (2006.01), C07K 11/02 (2006.01), C07K 14/32 (2006.01), C12Q 1/00 (2006.01), G01N 33/48 (2006.01)
Applicants: ADAERATA LIMITED PARTNERSHIP [CA/CA]; 3 Place Ville Marie, Suite 12350 Niveau L, #1-180 Montréal, Québec H3V 1E7 (CA).
UNIVERSITY OF MIAMI [US/US]; Office of Technology Transfer Life Science and Technology Park 1951 NW 7th Avenue Suite 300 Miami, Florida 33136 (US)
Inventors: DI NOIA, Javier M.; (CA).
VERDUN, Ramiro E.; (US).
METHOT, Stephen Patrick; (CA)
Agent: GOUDREAU GAGE DUBUC; 2000 McGill College Suite 2200 Montréal, Québec H3A 3H3 (CA)
Priority Data:
62/153,072 27.04.2015 US
Title (EN) MODULATING URACIL-DNA GLYCOSYLASE AND USES THEREOF
(FR) MODULATION D’URACILE-ADN GLYCOSYLASE ET UTILISATIONS ASSOCIÉES
Abstract: front page image
(EN)The present invention concerns a method for the prevention and/or treatment of an activation-induced deaminase (AID)-associated disease in a subject in need thereof, said method comprising administering an effective amount of an uracil-DNA glycosylase (UNG) inhibitor, or a composition comprising the inhibitor, and a pharmaceutically acceptable carrier, to a subject having pathogenic cells expressing AID, uracil-DNA glycosylase (UNG) and mismatch repair pathway (MMR). Also provided are kits comprising an UNG inhibitor, methods of stratifying a subject having an AID-associated disease, uses and compositions for use of the UNG inhibitor.
(FR)La présente invention concerne un procédé visant à prévenir et/ou à traiter une maladie associée à une désaminase induite par activation (AID) chez un sujet en ayant besoin, ledit procédé comprenant l'administration d'une quantité efficace d'un inhibiteur d’uracile-ADN glycosylase (UNG), ou d’une composition comprenant l'inhibiteur, et d’un support pharmaceutiquement acceptable, à un sujet présentant des cellules pathogènes exprimant une AID, l'uracile-ADN glycosylase (UNG) et un processus de réparation des mauvais appariements (MMR). L'invention concerne également des kits comprenant un inhibiteur de l'UNG, des procédés de stratification d'un sujet souffrant d’une maladie associée à une AID, des utilisations et des compositions mettant en œuvre l'inhibiteur de l'UNG.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)