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1. (WO2016170093) TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A MATRIX
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/170093 International Application No.: PCT/EP2016/058977
Publication Date: 27.10.2016 International Filing Date: 22.04.2016
Chapter 2 Demand Filed: 27.01.2017
IPC:
A61K 9/16 (2006.01) ,A61K 9/48 (2006.01) ,A61K 31/167 (2006.01) ,A61K 31/485 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
Applicants:
GRÜNENTHAL GMBH [DE/DE]; Zieglerstraße 6 52078 Aachen, DE
Inventors:
WENING, Klaus; DE
BARNSCHEID, Lutz; DE
GEISSLER, Anja; DE
DENKER, Jana; DE
REDMER, Jessica; DE
Agent:
KUTZENBERGER WOLFF & PARTNER; Theodor-Heuss-Ring 23 50668 Köln, DE
Priority Data:
15165070.224.04.2015EP
Title (EN) TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A MATRIX
(FR) COMBINAISON À DOSE FIXE INALTÉRABLE PRÉSENTANT UNE LIBÉRATION RAPIDE DE DEUX MÉDICAMENTS DE PARTICULES ET D'UNE MATRICE
Abstract:
(EN) The invention relates to a tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form according to the invention is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
(FR) La présente invention concerne une forme galénique pharmaceutique et inaltérable qui comporte deux ingrédients pharmacologiquement actifs, la forme galénique fournissant des conditions in vitro de libération rapide, préférablement de libération immédiate selon la Ph. eur., des deux ingrédients pharmacologiquement actifs. La forme galénique selon l'invention s'utilise dans le traitement combiné pharmaceutique qui est obtenu par l'administration des formes galéniques contenant plus d'un ingrédient pharmacologiquement actif sous la forme de combinaisons à dose fixe.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20160310486CA2983648AU2016251302IN201737037277MX2017013643JP2018513864
BR112017022335