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1. WO2016168708 - SYNTHESIS OF OMEGA FUNCTIONALIZED METHYLKETONES, 2-ALCOHOLS, 2-AMINES, AND DERIVATIVES THEREOF

Publication Number WO/2016/168708
Publication Date 20.10.2016
International Application No. PCT/US2016/027903
International Filing Date 15.04.2016
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
40
containing a carboxyl group
44
Polycarboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
45
Transferases (2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
51
Lyases (4)
C12N 1/20 (2006.01)
C12N 1/21 (2006.01)
C12P 7/44 (2006.01)
A61K 38/45 (2006.01)
A61K 38/51 (2006.01)
CPC
A61K 35/00
A61K 38/00
C12N 15/52
C12N 9/93
C12P 13/001
C12P 7/02
Applicants
  • WILLIAM MARSH RICE UNIVERSITY [US/US]; 6100 Main Street Houston, Texas 77005, US
Inventors
  • GONZALEZ, Ramon; US
  • CHEONG, Seokjung; US
  • CLOMBURG, James, M.; US
Agents
  • VALOIR, Tamsen; US
Priority Data
62/148,24816.04.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHESIS OF OMEGA FUNCTIONALIZED METHYLKETONES, 2-ALCOHOLS, 2-AMINES, AND DERIVATIVES THEREOF
(FR) SYNTHÈSE DE MÉTHYLCÉTONES, 2-ALCOOLS, 2-AMINES FONCTIONNALISÉS EN OMÉGA, ET DÉRIVÉS DE CES DERNIERS
Abstract
(EN)
The use of microorganisms to make omega-functionalized methyl ketones, 2-alcohols, 2- amines, and their derivatives, including lactams, lactones, α,ω-l -diamines, co- 1 -amino- 1- alcohols, co-amino methyl ketones, co-hydroxy methyl ketones, co-amino-2-alcohols, α,ω-1- diols. This is achieved through an iterative carbon chain elongation pathway that uses omega- functionalized CoA thioesters as primers and acetyl-CoA as the extender unit, in combination with various termination enzymes that act on the omega-functionalized beta-keto acyl-CoA intermediates of the pathway. The action of these termination enzymes on such intermediates yield the aforementioned products.
(FR)
L'invention concerne l'utilisation de micro-organismes pour la préparation de méthylcétones, 2-alcools, 2-amines fonctionnalisés en oméga, et leurs dérivés, y compris des lactames, lactones, α,ω-1-diamines, co-1-amino-1-alcools, co-amino méthylcétones, co-hydroxy méthylcétones, co-amino-2-alcools, α,ω-1-diols. Ce résultat est obtenu par l'intermédiaire de la voie d'allongement itératif des chaînes carbone qui utilise des CoA thioesters fonctionnalisés en oméga comme amorces et l'acétyl-CoA en tant que dispositif d'extension, en association avec diverses enzymes de terminaison qui agissent sur les intermédiaires beta-céto acyl-CoA fonctionnalisés en oméga de la voie. L'action de ces enzymes de terminaison sur de tels intermédiaires permet d'obtenir les produits susmentionnés.
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