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1. (WO2016164937) INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS

Pub. No.:    WO/2016/164937    International Application No.:    PCT/US2016/030843
Publication Date: Fri Oct 14 01:59:59 CEST 2016 International Filing Date: Thu May 05 01:59:59 CEST 2016
IPC: C07K 14/55
Applicants: AMGEN INC.
Inventors: BUTZ, Eric Alan
THOMSON, Christy Ann
GAVIN, Marc Alain
FOLTZ, Ian Nevin
XIA, Dong
ALCORN, Dina N.
LIM, Ai Ching
KETCHEM, Randal Robert
MANCHULENKO, Kathy
SEKIROV, Laura
BERRY, Kelly Ann
DE IMUS, Cyr Clovis Chua
AGRAWAL, Neeraj Jagdish
KANNAN, Gunasekaran
LI, Li
Title: INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
Abstract:
Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.