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1. WO2016151595 - ULTRASONIC URINARY BLADDER DRUG DELIVERY

Publication Number WO/2016/151595
Publication Date 29.09.2016
International Application No. PCT/IL2016/050326
International Filing Date 25.03.2016
IPC
A61M 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
37Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
A61M 25/10 2013.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
25Catheters; Hollow probes
10Balloon catheters
A61N 7/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
CPC
A61B 17/2202
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
22004using mechanical vibrations, e.g. ultrasonic shock waves
22012in direct contact with, or very close to, the obstruction or concrement
2202the ultrasound transducer being inside patient's body at the distal end of the catheter
A61B 17/225
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
225for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
A61B 2017/22007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
22004using mechanical vibrations, e.g. ultrasonic shock waves
22005Effects, e.g. on tissue
22007Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
A61B 2017/22008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
22004using mechanical vibrations, e.g. ultrasonic shock waves
22005Effects, e.g. on tissue
22007Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
22008used or promoted
A61B 2017/22082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
22082after introduction of a substance
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • VENSICA MEDICAL LTD. [IL]/[IL]
Inventors
  • GEVA, Avner
  • KUSHKULEY, Leonid
Agents
  • GEYRA, Assaf
Priority Data
62/138,57326.03.2015US
62/203,10910.08.2015US
62/273,50331.12.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ULTRASONIC URINARY BLADDER DRUG DELIVERY
(FR) ADMINISTRATION DE MÉDICAMENT VERS UNE VESSIE URINAIRE À L'AIDE D'ULTRASONS
Abstract
(EN)
A kit comprising: a urinary catheter comprising a first and a second longitudinal lumens; an ultrasonic transducer disposed about said catheter; a balloon mounted on said catheter, and enclosing said transducer; and a reservoir containing an acoustic coupling medium, wherein: said catheter further comprises a first opening in said first longitudinal lumen, said first opening disposed inside said balloon and configured to inflate said balloon with at least some of said acoustic coupling medium, said catheter further comprises a second opening in said second longitudinal lumen, said second opening disposed outside said balloon and configured to deliver a therapeutic fluid into the urinary bladder, around said balloon, and activation of said transducer in said urinary bladder causes cavitation bubbles to form in said therapeutic fluid adjacent an internal surface of the urinary bladder, and little or no cavitation bubbles are formed in said acoustic coupling medium in said balloon.
(FR)
La présente invention comprend un kit comprenant : un cathéter urinaire comprenant une première et une deuxième lumières longitudinales ; un transducteur à ultrasons disposé autour dudit cathéter ; un ballonnet monté sur ledit cathéter, et renfermant ledit transducteur ; et un réservoir contenant un milieu de couplage acoustique. Ledit cathéter comprend en outre une première ouverture dans ladite première lumière longitudinale, ladite première ouverture disposée à l'intérieur dudit ballonnet et conçue pour gonfler ledit ballonnet avec au moins une partie dudit milieu de couplage acoustique, ledit cathéter comprend en outre une seconde ouverture dans ladite deuxième lumière longitudinale, ladite seconde ouverture disposée à l'extérieur du ballonnet et conçue pour distribuer un fluide thérapeutique dans la vessie urinaire, autour dudit ballonnet, et l'activation dudit transducteur dans ladite vessie urinaire entraîne la formation de bulles de cavitation dans ledit fluide thérapeutique de manière adjacente à une surface interne de la vessie urinaire, et peu ou pas de bulles de cavitation sont formées dans ledit milieu de couplage acoustique dans ledit ballonnet.
Also published as
Latest bibliographic data on file with the International Bureau