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1. WO2016151500 - PARTICLES OF N-(5-CYANO-4-((2-METHOXYETHYL)AMINO)PYRIDIN-2-YL)-7-FORMYL-6-((4-METHYL-2- OXOPIPERAZIN-1-YL)METHYL)-3,4-DIHYDRO-1,8-NAPHTHYRIDINE-1(2H)-CARBOXAMIDE

Publication Number WO/2016/151500
Publication Date 29.09.2016
International Application No. PCT/IB2016/051633
International Filing Date 23.03.2016
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4375 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/4375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
Applicants
  • NOVARTIS AG [CH]/[CH] (AllExceptUS)
  • BUSCHMANN, Nicole [DE]/[CH] (US)
  • FAIRHURST, Robin Alec [GB]/[CH] (US)
  • FURET, Pascal [FR]/[CH] (US)
  • KNOEPFEL, Thomas [CH]/[CH] (US)
  • LEBLANC, Catherine [FR]/[CH] (US)
  • MAH, Robert [CA]/[CH] (US)
  • MALLET, Franck [FR]/[CH] (US)
  • MARTZ, Julie [FR]/[CH] (US)
  • LIAO, Lv [CN]/[CN] (US)
  • XIONG, Jing [CN]/[CN] (US)
  • HAN, Bo [CN]/[CN] (US)
  • WANG, Can [CN]/[CN] (US)
  • ZHAO, Xianglin [CN]/[CN] (US)
Inventors
  • BUSCHMANN, Nicole
  • FAIRHURST, Robin Alec
  • FURET, Pascal
  • KNOEPFEL, Thomas
  • LEBLANC, Catherine
  • MAH, Robert
  • MALLET, Franck
  • MARTZ, Julie
  • LIAO, Lv
  • XIONG, Jing
  • HAN, Bo
  • WANG, Can
  • ZHAO, Xianglin
Agents
  • NOVARTIS AG
Priority Data
PCT/CN2015/00020225.03.2015CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PARTICLES OF N-(5-CYANO-4-((2-METHOXYETHYL)AMINO)PYRIDIN-2-YL)-7-FORMYL-6-((4-METHYL-2- OXOPIPERAZIN-1-YL)METHYL)-3,4-DIHYDRO-1,8-NAPHTHYRIDINE-1(2H)-CARBOXAMIDE
(FR) PARTICULES DE N-(5-CYANO-4-((2-MÉTHOXYÉTHYL)AMINO)PYRIDIN-2-YL)-7-FORMYL-6-((4-MÉTHYL-2-OXOPIPÉRAZIN-1-YL)MÉTHYL)-3,4-DIHYDRO-1,8-NAPHTHYRIDINE-1(2H)-CARBOXAMIDE
Abstract
(EN)
The present invention relates to particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7- formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, to a process of making said particles, to pharmaceutical compositions comprising said particles and to method of treating cancers using said pharmaceutical compositions.
(FR)
Cette invention concerne des particules de N-(5-cyano-4-((2-méthoxyéthyl)amino)pyridin-2-yl)-7-formyl-6-((4-méthyl-2-oxopipérazin-1-yl)méthyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, un procédé de fabrication desdites particules, des compositions pharmaceutiques les contenant et une méthode destinée à traiter les cancers à l'aide desdites compositions pharmaceutiques.
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