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1. WO2016150799 - ASYMMETRIC BIS-ACRIDINES WITH ANTITUMOUR ACTIVITY AND THEIR USES

Publication Number WO/2016/150799
Publication Date 29.09.2016
International Application No. PCT/EP2016/055743
International Filing Date 17.03.2016
IPC
C07D 219/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
219Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
08Nitrogen atoms
10attached in position 9
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/435 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
CPC
A61K 31/473
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
473ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 219/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
219Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
08Nitrogen atoms
10attached in position 9
C07D 219/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
219Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
08Nitrogen atoms
10attached in position 9
12Amino-alkyl-amino radicals attached in position 9
Applicants
  • POLITECHNIKA GDAŃSKA [PL]/[PL]
Inventors
  • KONOPA, Jerzy Kazimierz
  • HOROWSKA, Barbara
  • PALUSZKIEWICZ, Ewa Maria
  • BOROWA-MAZGAJ, Barbara
  • AUGUSTIN, Ewa Anna
  • SKWARSKA, Anna
  • MAZERSKA, Zofia
Agents
  • WITEK, Rafał
Priority Data
15461518.120.03.2015EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ASYMMETRIC BIS-ACRIDINES WITH ANTITUMOUR ACTIVITY AND THEIR USES
(FR) BIS-ACRIDINES ASYMÉTRIQUES AYANT UNE ACTIVITÉ ANTITUMORALE ET LEURS UTILISATIONS
Abstract
(EN)
We disclose novel asymmetric bis-acridines with antitumour activity. These compounds are useful for use in pharmaceuticals, particularly in the treatment or the prevention of neoplasms.
(FR)
Cette invention concerne de nouvelles bis-acridines asymétriques ayant une activité antitumorale. Ces composés sont utiles dans des produits pharmaceutiques, en particulier pour traiter ou prévenir les néoplasmes.
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