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1. WO2016150396 - PROCESS OF SYNTHESIZING SUBSTITUTED PYRIDINE AND PYRIMIDINE COMPOUND

Publication Number WO/2016/150396
Publication Date 29.09.2016
International Application No. PCT/CN2016/077259
International Filing Date 24.03.2016
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • 中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA,CHINESE ACADEMY OF SCIENCES [CN]/[CN]
  • 山东罗欣药业集团有限公司 SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD. [CN]/[CN]
Inventors
  • 沈竞康 SHEN, Jingkang
  • 孟韬 MENG, Tao
  • 于霆 YU, Ting
  • 马兰萍 MA, Lanping
  • 王昕 WANG, Xin
  • 陈驎 CHEN, Lin
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
201510134261.725.03.2015CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PROCESS OF SYNTHESIZING SUBSTITUTED PYRIDINE AND PYRIMIDINE COMPOUND
(FR) PROCÉDÉ DE SYNTHÈSE DE DÉRIVÉ DE PYRIDINE ET DE PYRIMIDINE SUBSTITUÉ
(ZH) 取代吡啶并嘧啶类化合物的合成工艺
Abstract
(EN)
Provided is a process of synthesizing a substituted pyridine and pyrimidine compound. Particularly, provided is a method of preparing a compound of formula III via a compound of formula II', wherein the definition of each of groups is as described in the description. Compared with other methods, the method in the present invention has features of a high yield and a result product being easy to separate.
(FR)
La présente invention concerne un procédé de synthèse d'un dérivé de pyridine et de pyrimidine substitué. En particulier, le présente invention décrit un procédé de préparation d'un composé de formule III par l'intermédiaire d'un composé de formule II', une définition de chacun des groupes étant telle que décrite dans la description. Par comparaison avec d'autres procédés, le procédé de la présente invention présente les caractéristiques d'un rendement élevé et d'un produit final facile à séparer.
(ZH)
本发明提供了一类取代吡啶并嘧啶类化合物的合成工艺,具体地,本发明提供了一种通过式II'化合物制备式III化合物的方法,其中,各基团的定义如说明书中所述。本发明的路线与其他路线相比,具有产率高、产物易分离等特点。
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