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1. WO2016149516 - METHODS FOR THE TREATMENT OF BLADDER CANCER

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

IT IS CLAIMED:

1. A method for treating bladder cancer, comprising:

administering to an individual with bladder cancer liposomes comprising a folate targeting moiety and a prodrug of mitomycin C, the liposomes administered in an amount that yields a therapeutically-effective amount of mitomycin C for the treatment of bladder cancer.

2. The method of claim 1, wherein the prodrug is a conjugate of mitomycin C releasably attached to a lipophilic moiety.

3. The method of claim 1 or claim 2, wherein administering comprises administering via intravesical instillation.

4. The method of any one of claims 1-3, further comprising retaining the liposomes in the bladder for a period of between about 15 minutes and about 2 hours.

5. The method of any one of claims 2-4, further comprising administering to the individual a reducing agent to initiate release of the prodrug conjugate of mitomycin C from the attached lipophilic moiety.

6 The method of any one of claims 1-5, wherein the individual with bladder cancer is an individual with Stage 0 bladder cancer or with Stage I bladder cancer.

7. The method of any one of claims 1- 6, wherein the individual with bladder cancer is an individual with low-grade or high-grade bladder cancer.