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1. WO2016149169 - (INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2016/022262 ABV12169WOO1
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
14 March 2016 13 March 2015
Applicant
ABBVIE INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein G Ar, L 1, Z 1and Z 2are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nayl.7 and/or Nayl.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions for the treatment of pain.


6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 487/04 (2006.01)i; A61P 25/00 (2006.01)i; A61K 31/416 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
WO 2014066491 A1 (MERCK SHARP & DOHME [US]; PERO JOSEPH E [US]; LEHMAN HANNAH D G F [US]) 01 May 2014 (2014-05-01)
1-19
Formula Aa;paragraph [0165] - paragraph [0166]; claim 1
(2)
A
WO 2014135507 A1 (HOFFMANN LA ROCHE [CH]; HOFFMANN LA ROCHE [US]) 12 September 2014 (2014-09-12)
1-19
page 1, line 2 - line 4; claims 1, 18-21
(3)
E
WO 2016044386 A1 (ABBVIE INC [US]) 24 March 2016 (2016-03-24)
1-19
claim 1
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2014066491 A1
01 May 2014
AU 2013334664 A1
CA 2891056 A1
CN 104869992 A
EP 2911663 A1
JP 2015535252 A
KR 20150074123 A
US 2015284389 A1
WO 2014066491 A1
07 May 2015
01 May 2014
26 August 2015
02 September 2015
10 December 2015
01 July 2015
08 October 2015
01 May 2014
WO 2014135507 A1
12 September 2014
AU 2014224784 A1
CA 2897513 A1
CN 105143220 A
CR 20150447 A
EA 201591624 A1
EP 2964646 A1
JP 2016510054 A
KR 20150126355 A
PE 15392015 A1
PH 12015501843 A1
SG 11201507168X A
TW 201506023 A
US 2015376192 A1
WO 2014135507 A1
23 July 2015
12 September 2014
09 December 2015
08 October 2015
29 January 2016
13 January 2016
04 April 2016
11 November 2015
28 October 2015
07 December 2015
29 October 2015
16 February 2015
31 December 2015
12 September 2014
WO 2016044386 A1
24 March 2016
US 2016075692 A1
WO 2016044386 A1
17 March 2016
24 March 2016
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
19 April 2016
Date of mailing of the international search report:
09 May 2016
Authorized officer:
Miniejew, Catherine
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