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1. WO2016149169 - (INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE

Publication Number WO/2016/149169
Publication Date 22.09.2016
International Application No. PCT/US2016/022262
International Filing Date 14.03.2016
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61K 31/416 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
416condensed with carbocyclic ring systems, e.g. indazole
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
Applicants
  • ABBVIE INC. [US]/[US]
Inventors
  • DAANEN, Jerome
  • DEGOEY, David A.
  • FROST, Jennifer M.
  • JINKERSON, Tammie
  • LATSHAW, Steve
  • SHI, Lei
Agents
  • WARD, Michael J.
Priority Data
62/132,95313.03.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) (INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE
(FR) (INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES ET LEUR MÉTHODE D'UTILISATION
Abstract
(EN)
Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein GAr, L1, Z1and Z2are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nayl.7 and/or Nayl.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions for the treatment of pain.
(FR)
L'invention concerne des composés de formule (I) et des sels, esters, amides, ou formes radiomarquées pharmaceutiquement acceptables de ceux-ci. Dans la formule, GAr, L1, Z1 et Z2 ont la signification indiquée dans la description. Lesdits composés sont utiles pour traiter des états ou troubles dont la prévention est assurée par ou qui sont atténués par les canaux sodiques dépendants du potentiel, par exemple, Nav1.7 et/ou Nav1.8. L'invention concerne également des procédés pour la fabrication desdits composés. L'invention concerne en outre des compositions pharmaceutiques des composés de formule (I), et des méthodes d'utilisation des composés et compositions pour le traitement de la douleur.
Latest bibliographic data on file with the International Bureau